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    Tep4 Thioester-containing protein 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35248, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tep4provided by FlyBase
    Official Full Name
    Thioester-containing protein 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0041180
    Locus tag
    Dmel_CG10363
    See related
    AllianceGenome:FB:FBgn0041180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10363; CT29102; Dmel\CG10363; dTEPIV; Tep IV; TEP IV; tep4; TEP4; TEP4mel; tepIV; TepIV; TEPIV
    Summary
    Predicted to enable endopeptidase inhibitor activity. Involved in innate immune response. Located in extracellular space. Is expressed in several structures, including adult fat body; amnioserosa; anterior-posterior subdivision of organism; embryonic/larval midgut primordium; and visceral mesoderm derivative. Orthologous to human CD109 (CD109 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tep4 in Genome Data Viewer
    Location:
    37F1-37F1; 2-54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19548507..19556451)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19548507..19556451)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene refractory to sigma P Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Thioester-containing protein 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Thioester containing Protein-4 participates in the induction of the cellular immune response to the pathogen Photorhabdus. Shokal U, et al. Dev Comp Immunol, 2017 Nov. PMID 28642050
    2. Thioester-Containing Proteins 2 and 4 Affect the Metabolic Activity and Inflammation Response in Drosophila. Shokal U, et al. Infect Immun, 2018 May. PMID 29463615, Free PMC Article
    3. The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche. Benmimoun B, et al. Proc Natl Acad Sci U S A, 2015 Jul 21. PMID 26150488, Free PMC Article
    4. Thioester-Containing Protein-4 Regulates the Drosophila Immune Signaling and Function against the Pathogen Photorhabdus. Shokal U, et al. J Innate Immun, 2017. PMID 27771727, Free PMC Article
    5. Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization. Haller S, et al. EMBO Rep, 2018 May. PMID 29523648, Free PMC Article

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data support the protective role for TEP4 in the cellular immune response of Drosophila against the entomopathogen Photorhabdus
      Title: The Drosophila Thioester containing Protein-4 participates in the induction of the cellular immune response to the pathogen Photorhabdus.
    2. these findings generate novel insights into the immune role of TEP4 as a regulator and effector of the Drosophla melanogaster antibacterial immune response
      Title: Thioester-Containing Protein-4 Regulates the Drosophila Immune Signaling and Function against the Pathogen Photorhabdus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to fungus HEP PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Thioester-containing protein 4
    Names
    CG10363-PA
    CG10363-PB
    CG10363-PC
    CG10363-PD
    TEP
    Tep4-PA
    Tep4-PB
    Tep4-PC
    Tep4-PD
    Thioester-containing protein4
    thioester containing protein IV
    thiolester containing protein IV

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19548507..19556451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273662.1 → NP_001260591.1  Thioester-containing protein 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260591.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDF6, Q9NFV5
      Conserved Domains (6) summary
      cd02897
      Location:962 → 1259
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:748 → 839
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:106 → 199
      A2M_N; MG2 domain
      pfam07677
      Location:1369 → 1459
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1015 → 1261
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:508 → 633
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    2. NM_001273660.1 → NP_001260589.1  Thioester-containing protein 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260589.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD73, Q9NFV5
      Conserved Domains (6) summary
      cd02897
      Location:960 → 1257
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:746 → 837
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:106 → 199
      A2M_N; MG2 domain
      pfam07677
      Location:1367 → 1457
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1013 → 1259
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:508 → 633
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    3. NM_001273661.1 → NP_001260590.1  Thioester-containing protein 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260590.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDR0, Q9NFV5
      Conserved Domains (6) summary
      cd02897
      Location:982 → 1279
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:768 → 859
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:126 → 219
      A2M_N; MG2 domain
      pfam07677
      Location:1389 → 1479
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1035 → 1281
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:528 → 653
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    4. NM_078879.3 → NP_523603.2  Thioester-containing protein 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523603.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NFV5, Q9VIT9
      Related
      FBpp0080795
      Conserved Domains (6) summary
      cd02897
      Location:980 → 1277
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:766 → 857
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:126 → 219
      A2M_N; MG2 domain
      pfam07677
      Location:1387 → 1477
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1033 → 1279
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:528 → 653
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD73 M9PD73
    M9PDF6 M9PDF6
    M9PDR0 M9PDR0
    Q9NFV5 Q9NFV5
    Q9VIT9 Q9VIT9

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