CCHa2-R CCHamide-2 receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CCHa2-Rprovided by FlyBase
Official Full Name: CCHamide-2 receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0033058
Locus tag: Dmel_CG14593
See related: AllianceGenome:FB:FBgn0033058
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0131005.23; CCH2aR; CCHa2r; CCHa2R; CCHamide-2 R; CG14593; CG14594; Dmel\CG14593
Summary: Enables neuropeptide receptor activity. Involved in neuropeptide signaling pathway. Located in membrane. Is expressed in adult head; embryonic abdominal segment; larval central nervous system; larval insulin secreting cell of pars intercerebralis; and ventral midline of embryo. Orthologous to several human genes including BRS3 (bombesin receptor subtype 3) and GRPR (gastrin releasing peptide receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (6050949..6068680)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (1938454..1956185)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila.
Title: Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila.
Data indicate that the activation of CCHa2/CCHa2-R signaling promotes the sensation of good nutritional status in the larval brain, leading to Dilp-dependent tissue growth.
Title: Coupling of growth to nutritional status: The role of novel periphery-to-brain signaling by the CCHa2 peptide in Drosophila melanogaster.
genetic disruption of either CCHa2 or CCHa2-R caused almost identical defects in larval growth and developmental timing
Title: The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster.
Expression patterns of the Drosophila neuropeptide CCHamide-2 and its receptor may suggest hormonal signaling from the gut to the brain.
Title: Expression patterns of the Drosophila neuropeptide CCHamide-2 and its receptor may suggest hormonal signaling from the gut to the brain.
G-protein-coupled receptors coded for by genes CG14593 and CG30106 that are selectively activated by Drosophila CCH-amide-1 and CCH-amide-2, respectively, were cloned.
Title: The Drosophila genes CG14593 and CG30106 code for G-protein-coupled receptors specifically activated by the neuropeptides CCHamide-1 and CCHamide-2.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: CCHa2-R-PA; CCHa2-R-PB; CCHa2-R-PC; CG14593-PA; CG14593-PB; CG14593-PC

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The following sections contain reference sequences that belong to a specific genome build. Explain