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    ProRS-m Prolyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38331, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ProRS-mprovided by FlyBase
    Official Full Name
    Prolyl-tRNA synthetase, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027082
    Locus tag
    Dmel_CG12186
    See related
    AllianceGenome:FB:FBgn0027082
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aats-pro; CG12186; Dmel\CG12186; ProRS; PRS
    Summary
    Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 75. Orthologous to human PARS2 (prolyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ProRS-m in Genome Data Viewer
    Location:
    62E8-62E8; 3-3 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2650161..2651850, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2650161..2651850, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Snurportin Neighboring gene fife Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
    2. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article
    3. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
    4. Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster. Takai A, et al. Int J Mol Sci, 2020 Sep 3. PMID 32899411, Free PMC Article
    5. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in prolyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prolyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in prolyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Prolyl-tRNA synthetase, mitochondrial
    Names
    CG12186-PA
    CG12186-PB
    ProRS-m-PA
    ProRS-m-PB
    Prolyl-tRNA synthetase
    NP_001261337.1
    NP_647737.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2650161..2651850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139480.3 → NP_647737.1  Prolyl-tRNA synthetase, mitochondrial, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647737.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P96, Q9VZY9
      Related
      FBpp0072825
      Conserved Domains (3) summary
      PRK09194
      Location:3 → 422
      PRK09194; prolyl-tRNA synthetase; Provisional
      cd00779
      Location:24 → 313
      ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00861
      Location:328 → 428
      ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...

    2. NM_001274408.1 → NP_001261337.1  Prolyl-tRNA synthetase, mitochondrial, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261337.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBJ9
      Conserved Domains (1) summary
      cl00268
      Location:24 → 118
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBJ9 M9PBJ9
    Q6NQW5 Q6NQW5
    Q86P96 Q86P96
    Q9VZY9 Q9VZY9

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