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    spo spook [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38631, updated on 9-Dec-2024

    Summary

    Official Symbol
    spoprovided by FlyBase
    Official Full Name
    spookprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003486
    Locus tag
    Dmel_CG10594
    See related
    AllianceGenome:FB:FBgn0003486
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    307a1; CG10594; Cyp307a1; CYP307A1; CYP307A1-Dm; Dmel\CG10594; Dmspo; Spo
    Summary
    Predicted to enable heme binding activity and oxidoreductase activity. Involved in several processes, including digestive tract development; ecdysone biosynthetic process; and embryonic development via the syncytial blastoderm. Located in endoplasmic reticulum. Is expressed in several structures, including amnioserosa; amnioserosa primordium; follicle cell; yolk; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See spo in Genome Data Viewer
    Location:
    64D5-64D5; 3-14 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5590083..5592571, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5583183..5585671, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene bc10 Neighboring gene small non-coding RNA 357 Neighboring gene Msr-110 Neighboring gene lethal (3) persistent salivary gland 2 Neighboring gene Alkaline phosphatase 10 Neighboring gene Alkaline phosphatase 9

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heme binding ISM
    Inferred from Sequence Model
    more info
    PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity ISM
    Inferred from Sequence Model
    more info
    PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ecdysone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic development via the syncytial blastoderm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in head involution IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in midgut development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    spook
    Names
    CG10594-PA
    CG10594-PC
    spo-PA
    spo-PC
    NP_001286943.1
    NP_647975.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5590083..5592571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300014.1NP_001286943.1  spook, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286943.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZ84, Q9VRM7
      UniProtKB/TrEMBL
      H8F4V5
      Conserved Domains (1) summary
      cl12078
      Location:56540
      p450; Cytochrome P450
    2. NM_139718.3NP_647975.2  spook, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647975.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZ84, Q9VRM7
      UniProtKB/TrEMBL
      H8F4V5
      Related
      FBpp0076836
      Conserved Domains (1) summary
      cl12078
      Location:56540
      p450; Cytochrome P450