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    Ppat-Dpck Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38647, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ppat-Dpckprovided by FlyBase
    Official Full Name
    Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035632
    Locus tag
    Dmel_CG10575
    See related
    AllianceGenome:FB:FBgn0035632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10575; dCOASY; Dmel\CG10575; DPCK/PPAT; dPPAT-DPCK; PPAT-DPCK
    Summary
    Predicted to enable dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Involved in triglyceride homeostasis. Predicted to be located in mitochondrion. Is expressed in adult head. Used to study neurodegeneration with brain iron accumulation 6. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia type 12. Orthologous to human COASY (Coenzyme A synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ppat-Dpck in Genome Data Viewer
    Location:
    64E7-64E7; 3-15 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5767017..5768794, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5760117..5761894, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA:CR43603 Neighboring gene antisense RNA:CR45831 Neighboring gene Thioredoxin-like Neighboring gene scrawny Neighboring gene viriato

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis. Srinivasan B, et al. Nat Chem Biol, 2015 Oct. PMID 26322826
    2. CoA protects against the deleterious effects of caloric overload in Drosophila. Palanker Musselman L, et al. J Lipid Res, 2016 Mar. PMID 26805007, Free PMC Article
    3. Drosophila phosphopantothenoylcysteine synthetase is required for tissue morphogenesis during oogenesis. Bosveld F, et al. BMC Res Notes, 2008 Aug 29. PMID 18759961, Free PMC Article
    4. De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system. Bosveld F, et al. Hum Mol Genet, 2008 Jul 1. PMID 18407920
    5. Metabolic pathways modulate the neuronal toxicity associated with fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Hum Mol Genet, 2019 Mar 15. PMID 30476102, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dephospho-CoA kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dephospho-CoA kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dephospho-CoA kinase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables pantetheine-phosphate adenylyltransferase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coenzyme A biosynthetic process ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional phosphopantetheine adenylyltransferase - Dephospho-CoA kinase
    Names
    4'-phosphopantetheine adenylyltransferase - dephospho-CoA kinase
    CG10575-PA
    Ppat-Dpck-PA
    NP_647985.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5767017..5768794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139728.2 → NP_647985.1  bifunctional phosphopantetheine adenylyltransferase - Dephospho-CoA kinase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647985.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QT3, Q9VRP4
      Related
      FBpp0076826
      Conserved Domains (3) summary
      cd02164
      Location:147 → 290
      PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
      COG0237
      Location:311 → 510
      CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
      cd02022
      Location:313 → 494
      DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRP4 Q9VRP4

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