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    Ilp3 Insulin-like peptide 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39151, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ilp3provided by FlyBase
    Official Full Name
    Insulin-like peptide 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0044050
    Locus tag
    Dmel_CG14167
    See related
    AllianceGenome:FB:FBgn0044050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14167; dilp; Dilp; DILP; dilp 3; Dilp 3; DILP 3; dilp-3; dILP-3; Dilp-3; DILP-3; Dilp1-5; dilp3; dIlp3; dILp3; dILP3; Dilp3; DILP3; DILPs; dipl3; dlp; dlp3; Dmel\CG14167; Ilp; Ilp-3; ilp3; IlP3; ILP3; ILPs
    Summary
    Predicted to enable insulin receptor binding activity. Involved in several processes, including insulin receptor signaling pathway; locomotor rhythm; and negative regulation of entry into reproductive diapause. Located in extracellular space. Is expressed in several structures, including adult midgut circular muscle cell; gastric caecum; gut section; insulin secreting cell of pars intercerebralis; and larval brain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ilp3 in Genome Data Viewer
    Location:
    67C8-67C8; 3-31 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9801298..9802120, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9794398..9795220, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Insulin-like peptide 1 Neighboring gene Insulin-like peptide 2 Neighboring gene Insulin-like peptide 4 Neighboring gene uncharacterized protein Neighboring gene Insulin-like peptide 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ablation of insulin-producing cells prevents obesity but not premature mortality caused by a high-sugar diet in Drosophila. Al Saud SN, et al. Proc Biol Sci, 2015 Feb 7. PMID 25520354, Free PMC Article
    2. Cell biology. Insulin finds its niche. Cheetham SW, et al. Science, 2013 May 17. PMID 23687033
    3. Glut1 Functions in Insulin-Producing Neurons to Regulate Lipid and Carbohydrate Storage in Drosophila. Kauffman MR, et al. Biomolecules, 2024 Aug 20. PMID 39199423, Free PMC Article
    4. Solanum anguivi Lam. fruit preparations counteract the negative effects of a high-sugar diet on the glucose metabolism in Drosophila melanogaster. Nakitto AMS, et al. Food Funct, 2021 Oct 4. PMID 34606536
    5. A triple drug combination targeting components of the nutrient-sensing network maximizes longevity. Castillo-Quan JI, et al. Proc Natl Acad Sci U S A, 2019 Oct 15. PMID 31570569, Free PMC Article

    See all (421) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using two long-lived IIS models, namely Drosophila lacking three insulin-like peptides (dilp2-3,5(-/-)) and mice lacking insulin receptor substrate 1 (Irs1(-/-)), and two independent translation assays, polysome profiling and radiolabeled amino acid incorporation, we show that reduced IIS lowers translation in these organisms
      Title: Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice.
    2. Results found that virgin females with knockout mutations of Ilp2, Ilp3 and Ilp5 show high mating success rate with higher locomotion.
      Title: Knockout mutations of insulin-like peptide genes enhance sexual receptivity in Drosophila virgin females.
    3. Dilp3 is uniquely required for the sugar-mediated activation of TOR signalling and suppression of autophagy in the larval fat body.
      Title: Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3.
    4. show that the DILP-producing median neurosecretory cells are required to mediate nearly all of the response of lifespan and some of the response of fecundity to yeast levels
      Title: DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of entry into reproductive diapause IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to carbohydrate IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Insulin-like peptide 3
    Names
    CG14167-PA
    Ilp3-PA
    Insulin-like peptide
    drosophila insulin-like peptide 3
    insulin/insulin-like growth factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9801298..9802120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140103.3 → NP_648360.2  Insulin-like peptide 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648360.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VT52
      UniProtKB/TrEMBL
      E7BBS2, Q4V6A0
      Conserved Domains (1) summary
      cd04366
      Location:33 → 114
      IlGF_insulin_bombyxin_like; IlGF_like family, insulin_bombyxin_like subgroup. Members include a number of peptides including insulin, insulin-like growth factors I and II, insect prothoracicotropic hormone (bombyxin), locust insulin-related peptide (LIRP), molluscan insulin-related ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VT52.2 Q9VT52

    Gene LinkOut

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