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    dpr10 defective proboscis extension response 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39180, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpr10provided by FlyBase
    Official Full Name
    defective proboscis extension response 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0052057
    Locus tag
    Dmel_CG32057
    See related
    AllianceGenome:FB:FBgn0052057
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE37920; CG14158; CG14159; CG32057; CT33762; Dmel\CG32057; Dpr-10; Dpr10
    Summary
    Involved in synapse organization. Located in neuron projection membrane. Is expressed in adult mushroom body alpha'-lobe; adult mushroom body alpha-lobe; adult mushroom body gamma-lobe; larval ventral nerve cord; and medulla. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dpr10 in Genome Data Viewer
    Location:
    67D9-67D10; 3-32 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10147454..10186108, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10140554..10179208, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 6 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44538 Neighboring gene ectodermal

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dpr10 and Nocte are required for Drosophila motor axon pathfinding. Lobb-Rabe M, et al. Neural Dev, 2022 Oct 21. PMID 36271407, Free PMC Article
    2. Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity. Ashley J, et al. Elife, 2019 Feb 4. PMID 30714906, Free PMC Article
    3. hkb is required for DIP-α expression and target recognition in the Drosophila neuromuscular circuit. Wang Y, et al. Commun Biol, 2024 Apr 27. PMID 38678127, Free PMC Article
    4. Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila. Cheng S, et al. Elife, 2019 Jan 28. PMID 30688651, Free PMC Article
    5. Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10. Venkatasubramanian L, et al. Elife, 2019 Feb 4. PMID 30714901, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose a model whereby DIP-alpha and Dpr10 on opposing synaptic partners interact with each other to generate proper motor neuron connectivity.
      Title: Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity.
    2. different leg Motor neurons depend on the DIP-alpha and Dpr10 interaction to varying degrees that correlate with the morphological complexity of the Motor neurons and their muscle targets.
      Title: Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10.
    3. These studies support an important role for the DIP/Dpr protein interaction network in regulating cell-type-specific connectivity patterns.
      Title: Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in sensory perception of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    defective proboscis extension response 10
    Names
    CG32057-PA
    CG32057-PB
    CG32057-PC
    CG32057-PD
    dpr10-PA
    dpr10-PB
    dpr10-PC
    dpr10-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      10147454..10186108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168398.2 → NP_729592.1  defective proboscis extension response 10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729592.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS24, Q9VT83
      Related
      FBpp0076038
      Conserved Domains (3) summary
      smart00408
      Location:217 → 287
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:210 → 297
      IG_like; Immunoglobulin like
      cl11960
      Location:63 → 143
      Ig; Immunoglobulin domain

    2. NM_001274747.1 → NP_001261676.1  defective proboscis extension response 10, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261676.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF17, Q8MS24
      Conserved Domains (3) summary
      smart00408
      Location:171 → 241
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:164 → 251
      IG_like; Immunoglobulin like
      cl11960
      Location:63 → 143
      Ig; Immunoglobulin domain

    3. NM_168397.2 → NP_729591.1  defective proboscis extension response 10, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729591.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS24, Q9VT83
      Related
      FBpp0076037
      Conserved Domains (3) summary
      smart00408
      Location:217 → 287
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:210 → 297
      IG_like; Immunoglobulin like
      cl11960
      Location:63 → 143
      Ig; Immunoglobulin domain

    4. NM_168399.2 → NP_729593.1  defective proboscis extension response 10, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729593.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS24, Q9VT83
      Related
      FBpp0076039
      Conserved Domains (3) summary
      smart00408
      Location:217 → 287
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:210 → 297
      IG_like; Immunoglobulin like
      cl11960
      Location:63 → 143
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PF17 M9PF17
    Q8MS24 Q8MS24
    Q9VT83 Q9VT83

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