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    Grx1 Glutaredoxin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grx1provided by FlyBase
    Official Full Name
    Glutaredoxin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036820
    Locus tag
    Dmel_CG6852
    See related
    AllianceGenome:FB:FBgn0036820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH24739; CG6852; Dmel\CG6852
    Summary
    Predicted to enable glutathione disulfide oxidoreductase activity. Involved in copper ion homeostasis and response to copper ion. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Grx1 in Genome Data Viewer
    Location:
    75E2-75E2; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18869230..18870057)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18862330..18863157)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dysbindin Neighboring gene Rad9 Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 3 Neighboring gene UDP-glucose-glycoprotein glucosyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The endogenous antioxidant ability of royal jelly in Drosophila is independent of Keap1/Nrf2 by activating oxidoreductase activity. Wen D, et al. Insect Sci, 2024 Apr. PMID 37632209
    2. Evidence for a role for the putative Drosophila hGRX1 orthologue in copper homeostasis. Mercer SW, et al. Biometals, 2016 Aug. PMID 27379771
    3. Identification and mapping of induced chromosomal deletions using sequence polymorphisms. Vanrobays E, et al. Biotechniques, 2010 Jan. PMID 20078428
    4. Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease. Scherzer CR, et al. Hum Mol Genet, 2003 Oct 1. PMID 12915459
    5. A Hopscotch-chromatin connection. Betz A, et al. Nat Genet, 2006 Sep. PMID 16941005

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutathione oxidoreductase (glutathione) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in copper ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutaredoxin 1
    Names
    CG6852-PA
    CG6852-PC
    Grx1-PA
    Grx1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18869230..18870057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259898.2 → NP_001246827.1  glutaredoxin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246827.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVT6
      Conserved Domains (1) summary
      cd03419
      Location:31 → 111
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

    2. NM_140808.3 → NP_649065.1  glutaredoxin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVT6
      Related
      FBpp0074830
      Conserved Domains (1) summary
      cd03419
      Location:31 → 111
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVT6 Q9VVT6

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