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    Pde6 Phosphodiesterase 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41760, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pde6provided by FlyBase
    Official Full Name
    Phosphodiesterase 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0038237
    Locus tag
    Dmel_CG8279
    See related
    AllianceGenome:FB:FBgn0038237
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8279; Dmel\CG8279; DmPDE5/6; DmPDE6; PDE5/6; PDE6
    Summary
    Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP metabolic process and negative regulation of nucleobase-containing compound transport. Located in apical plasma membrane. Is expressed in adult head and adult main segment of Malpighian tubule. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and cone-rod dystrophy. Orthologous to human PDE5A (phosphodiesterase 5A) and PDE6C (phosphodiesterase 6C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Pde6 in Genome Data Viewer
    Location:
    88C3-88C6; 3-55 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14513901..14558304, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10339623..10384026, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene HTRA2-related serine protease Neighboring gene mitochondrial ribosomal protein L11 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 313a1 Neighboring gene long non-coding RNA:CR46021 Neighboring gene long non-coding RNA:CR46022 Neighboring gene long non-coding RNA:CR46023 Neighboring gene uncharacterized protein Neighboring gene Jig

    Genomic regions, transcripts, and products

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    phosphodiesterase 6
    Names
    CG8279-PB
    CG8279-PC
    CG8279-PD
    Pde6-PB
    Pde6-PC
    Pde6-PD
    NP_001262566.1
    NP_001287327.1
    NP_650369.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14513901..14558304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142112.5NP_650369.3  phosphodiesterase 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650369.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TW8, Q9VFI9
      UniProtKB/TrEMBL
      A0A0B4LH87
      Conserved Domains (2) summary
      smart00065
      Location:247406
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:717950
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. NM_001275637.2NP_001262566.1  phosphodiesterase 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262566.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFZ3
      Conserved Domains (2) summary
      smart00065
      Location:247406
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:717950
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    3. NM_001300398.1NP_001287327.1  phosphodiesterase 6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287327.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TW8, Q9VFI9
      UniProtKB/TrEMBL
      A0A0B4LH87
      Conserved Domains (2) summary
      smart00065
      Location:247406
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:717950
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase