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    CG34354 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740528, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG34354provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085383
    Locus tag
    Dmel_CG34354
    See related
    AllianceGenome:FB:FBgn0085383
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12425; CG12852; cg4787; CG4787; Dmel\CG34354
    Old locus tag
    CG12425; CG12852; CG4787; Dmel_CG12425; Dmel_CG12852; Dmel_CG4787
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of mRNA processing. Predicted to be located in nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG34354 in Genome Data Viewer
    Location:
    98C1-98C2; 3-95 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28146880..28240526)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23972602..24066248)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46077 Neighboring gene long non-coding RNA:CR46076 Neighboring gene long non-coding RNA:CR46078 Neighboring gene long non-coding RNA:CR46079 Neighboring gene long non-coding RNA:CR46080 Neighboring gene antisense RNA:CR45041 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila SMN2 minigene reporter model identifies moxifloxacin as a candidate therapy for SMA. Konieczny P, et al. FASEB J, 2020 Feb. PMID 31909520
    2. Evolutionary plasticity of polycomb/trithorax response elements in Drosophila species. Hauenschild A, et al. PLoS Biol, 2008 Oct 28. PMID 18959483, Free PMC Article
    3. A genome-wide association study for nutritional indices in Drosophila. Unckless RL, et al. G3 (Bethesda), 2015 Jan 12. PMID 25583649, Free PMC Article
    4. Highly constrained intergenic Drosophila ultraconserved elements are candidate ncRNAs. Kern AD, et al. Genome Biol Evol, 2015 Jan 23. PMID 25618141, Free PMC Article
    5. Transcriptional Programs of Circuit Assembly in the Drosophila Visual System. Kurmangaliyev YZ, et al. Neuron, 2020 Dec 23. PMID 33125872

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 28173725-28181097 mobile_element_type = transposon:mdg1{}1442

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG34354-PD
    CG34354-PE
    CG34354-PF
    CG34354-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28146880..28240526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170285.3 → NP_001163756.2  uncharacterized protein Dmel_CG34354, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163756.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ00
      Conserved Domains (2) summary
      cd12353
      Location:97 → 171
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:202 → 278
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

    2. NM_001104483.3 → NP_001097953.2  uncharacterized protein Dmel_CG34354, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097953.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0H4Y1N6, A8JPX0
      Conserved Domains (2) summary
      cd12353
      Location:97 → 171
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:202 → 278
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

    3. NM_001316621.1 → NP_001303550.1  uncharacterized protein Dmel_CG34354, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GV08
      Conserved Domains (2) summary
      cd12353
      Location:97 → 171
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:202 → 278
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

    4. NM_001170284.3 → NP_001163755.2  uncharacterized protein Dmel_CG34354, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163755.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ00
      Conserved Domains (2) summary
      cd12353
      Location:97 → 171
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:202 → 278
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A126GV08 A0A126GV08
    A8JPX0 A8JPX0
    E1JJ00 E1JJ00

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