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    CG12355 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768954, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12355provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040805
    Locus tag
    Dmel_CG12355
    See related
    AllianceGenome:FB:FBgn0040805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12355; MP17; MP17L
    Summary
    Predicted to enable monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human MPV17L (MPV17 mitochondrial inner membrane protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12355 in Genome Data Viewer
    Location:
    71D3-71D3; 3-43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15492964..15495549, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15486064..15488649, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene cocoon Neighboring gene Ran-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila model of the neurological symptoms in Mpv17-related diseases. Kodani A, et al. Sci Rep, 2022 Dec 31. PMID 36587049, Free PMC Article
    2. Drosophila Mpv17 forms an ion channel and regulates energy metabolism. Corrà S, et al. iScience, 2023 Oct 20. PMID 37810222, Free PMC Article
    3. A Systematic Cell-Based Analysis of Localization of Predicted Drosophila Peroxisomal Proteins. Baron MN, et al. Traffic, 2016 May. PMID 26865094
    4. Rosy Beginnings: Studying Peroxisomes in Drosophila. Pridie C, et al. Front Cell Dev Biol, 2020. PMID 32984330, Free PMC Article
    5. Peroxisome Protein Prediction in Drosophila melanogaster. Anderson-Baron M, et al. Subcell Biochem, 2018. PMID 30378026

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12355-PA
    CG12355-PB
    CG12355-PD
    CG12355-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15492964..15495549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169976.1 → NP_001163447.1  uncharacterized protein Dmel_CG12355, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163447.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IL61, Q7KUN0
      Conserved Domains (1) summary
      pfam04117
      Location:3 → 65
      Mpv17_PMP22; Mpv17 / PMP22 family

    2. NM_001274946.1 → NP_001261875.1  uncharacterized protein Dmel_CG12355, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261875.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNT1
      Conserved Domains (1) summary
      pfam04117
      Location:116 → 178
      Mpv17_PMP22; Mpv17 / PMP22 family

    3. NM_001104140.3 → NP_001097610.1  uncharacterized protein Dmel_CG12355, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNT1
      Conserved Domains (1) summary
      pfam04117
      Location:116 → 178
      Mpv17_PMP22; Mpv17 / PMP22 family

    4. NM_206369.3 → NP_996091.1  uncharacterized protein Dmel_CG12355, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996091.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IL61, Q7KUN0
      Conserved Domains (1) summary
      pfam04117
      Location:3 → 65
      Mpv17_PMP22; Mpv17 / PMP22 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNT1 A8JNT1
    Q7KUN0 Q7KUN0

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