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    vex vexed [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32033, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vexprovided by FlyBase
    Official Full Name
    vexedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259241
    Locus tag
    Dmel_CG42339
    See related
    AllianceGenome:FB:FBgn0259241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12626; CG15204; CG42339; Dmel\CG42339
    Old locus tag
    Dmel_CG12626; Dmel_CG15204
    Summary
    Orthologous to human SBSPON (somatomedin B and thrombospondin type 1 domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See vex in Genome Data Viewer
    Location:
    9F13-10A3; 1-33 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10967722..11039901, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10861755..10933934, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Myosin 10A Neighboring gene Rab at 9Fb Neighboring gene C901 Neighboring gene SET and MYND domain containing, arthropod-specific, member 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vexed mutations promote degeneration of dopaminergic neurons through excessive activation of the innate immune response. Davis J, et al. NPJ Parkinsons Dis, 2022 Nov 2. PMID 36323700, Free PMC Article
    2. Characterizing dopaminergic neuron vulnerability using genome-wide analysis. Davis J, et al. Genetics, 2021 Aug 9. PMID 34038543, Free PMC Article
    3. Analysis of immune-related genes during Nora virus infection of Drosophila melanogaster using next generation sequencing. Lopez W, et al. AIMS Microbiol, 2018. PMID 29707694, Free PMC Article
    4. Characteristics of molecular-genetic organization of intercalary heterochromatin band 10A1-2 in X chromosome of Drosophila melanogaster. Babenko VN, et al. Dokl Biochem Biophys, 2009 Jan-Feb. PMID 19341102
    5. Genetic organization of interphase chromosome bands and interbands in Drosophila melanogaster. Zhimulev IF, et al. PLoS One, 2014. PMID 25072930, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    vexed
    Names
    CG42339-PA
    CG42339-PB
    vex-PA
    vex-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10967722..11039901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132446.4 → NP_572674.3  vexed, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572674.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZ43
      Conserved Domains (2) summary
      smart00209
      Location:86 → 136
      TSP1; Thrombospondin type 1 repeats
      pfam01033
      Location:53 → 79
      Somatomedin_B; Somatomedin B domain

    2. NM_144209.3 → NP_652466.2  vexed, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652466.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V446, Q9VZ42
      Conserved Domains (1) summary
      pfam01033
      Location:53 → 81
      Somatomedin_B; Somatomedin B domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V446 Q4V446
    Q9VZ43 Q9VZ43

    Gene LinkOut

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