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    r rudimentary [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rprovided by FlyBase
    Official Full Name
    rudimentaryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003189
    Locus tag
    Dmel_CG18572
    See related
    AllianceGenome:FB:FBgn0003189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACT; CAD; CG18572; CG4601; CPS; csp2; DHO; Dmel\CG18572; DRORUD; fs(1)829; fs(1)M34; GAT; l(1)Ab; PYR1; R; Su(b)
    Summary
    Enables aspartate carbamoyltransferase activity; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; and dihydroorotase activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process and glutamine metabolic process. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 50. Orthologous to human CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    14F5-15A1; 1-54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16655359..16668712)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16549392..16562745)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene methuselah-like 1 Neighboring gene long non-coding RNA:CR46147 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nuclear envelope integral membrane protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and biochemical properties of revertants at the rudimentary locus in Drosophila melanogaster. Tsubota SI, et al. Mol Gen Genet, 1981. PMID 6120439
    2. Hybrid dysgenesis-induced revertants of insertions at the 5' end of the rudimentary gene in Drosophila melanogaster: transposon-induced control mutations. Tsubota S, et al. Genetics, 1986 Sep. PMID 3021567, Free PMC Article
    3. Molecular organization of the rudimentary gene of Drosophila melanogaster. Freund JN, et al. J Mol Biol, 1986 May 5. PMID 3023623
    4. Repair of a genetically-caused defect in oogenesis in Drosophila melanogaster by transplantation of cytoplasm from wild-type eggs and by injection of pyrimidine nucleosides. Okada M, et al. Dev Biol, 1974 Mar. PMID 4207297
    5. The biochemical genetics of rudimentary mutants of Drosophila melanogaster. I. Aspartate carbamoyltransferase levels in complementing and non-complementing strains. Norby S. Hereditas, 1973. PMID 4218218

    See all (148) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IC
    Inferred by Curator
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amino acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate carbamoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartate carbamoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aspartate carbamoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate carbamoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dihydroorotase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydroorotase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydroorotase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutamine binding IC
    Inferred by Curator
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine metabolic process IC
    Inferred by Curator
    more info
    		  
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rudimentary
    Names
    CG18572-PA
    CG18572-PD
    CG18572-PE
    Suppressor-of-black
    carbamoylphosphate synthetase
    r-PA
    r-PD
    r-PE
    rudimentary gene
    suppressor of black
    NP_001285343.1
    NP_523377.1
    NP_996488.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16655359..16668712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078653.2 → NP_523377.1  rudimentary, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523377.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5X540, O97163, P05990, Q26376, Q7KUX4, Q8SXM0, Q9VXD5
      UniProtKB/TrEMBL
      X2JFG0
      Related
      FBpp0088675
      Conserved Domains (13) summary
      cd01744
      Location:196 → 371
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      PLN02527
      Location:1918 → 2220
      PLN02527; aspartate carbamoyltransferase
      cd01316
      Location:1475 → 1821
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:1327 → 1453
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      TIGR01368
      Location:7 → 376
      CPSaseIIsmall; carbamoyl-phosphate synthase, small subunit
      TIGR01369
      Location:403 → 1455
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      pfam00185
      Location:2067 → 2216
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00988
      Location:7 → 151
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      pfam02729
      Location:1919 → 2060
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      pfam02786
      Location:524 → 726
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      pfam02787
      Location:815 → 935
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
      cl17255
      Location:1084 → 1265
      ATP-grasp_4; ATP-grasp domain
      cl21455
      Location:947 → 1149
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_206765.3 → NP_996488.2  rudimentary, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5X540, O97163, P05990, Q26376, Q7KUX4, Q8SXM0, Q9VXD5
      UniProtKB/TrEMBL
      X2JFG0
      Conserved Domains (13) summary
      cd01744
      Location:196 → 371
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      PLN02527
      Location:1918 → 2220
      PLN02527; aspartate carbamoyltransferase
      cd01316
      Location:1475 → 1821
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:1327 → 1453
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      TIGR01368
      Location:7 → 376
      CPSaseIIsmall; carbamoyl-phosphate synthase, small subunit
      TIGR01369
      Location:403 → 1455
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      pfam00185
      Location:2067 → 2216
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00988
      Location:7 → 151
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      pfam02729
      Location:1919 → 2060
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      pfam02786
      Location:524 → 726
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      pfam02787
      Location:815 → 935
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
      cl17255
      Location:1084 → 1265
      ATP-grasp_4; ATP-grasp domain
      cl21455
      Location:947 → 1149
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001298414.1 → NP_001285343.1  rudimentary, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285343.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5X540, O97163, P05990, Q26376, Q7KUX4, Q8SXM0, Q9VXD5
      UniProtKB/TrEMBL
      X2JFG0
      Conserved Domains (13) summary
      cd01744
      Location:196 → 371
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      PLN02527
      Location:1918 → 2220
      PLN02527; aspartate carbamoyltransferase
      cd01316
      Location:1475 → 1821
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:1327 → 1453
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      TIGR01368
      Location:7 → 376
      CPSaseIIsmall; carbamoyl-phosphate synthase, small subunit
      TIGR01369
      Location:403 → 1455
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      pfam00185
      Location:2067 → 2216
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00988
      Location:7 → 151
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      pfam02729
      Location:1919 → 2060
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      pfam02786
      Location:524 → 726
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      pfam02787
      Location:815 → 935
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
      cl17255
      Location:1084 → 1265
      ATP-grasp_4; ATP-grasp domain
      cl21455
      Location:947 → 1149
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05990.3 P05990
    X2JFG0 X2JFG0

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