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    fbp fructose-1,6-bisphosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35265, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fbpprovided by FlyBase
    Official Full Name
    fructose-1,6-bisphosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032820
    Locus tag
    Dmel_CG31692
    See related
    AllianceGenome:FB:FBgn0032820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10611; CG31692; Dmel\CG31692; Fbp; FbPase
    Summary
    Predicted to enable fructose 1,6-bisphosphate 1-phosphatase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and hexose metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; embryonic/larval crystal cell; larval muscle cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1) and FBP2 (fructose-bisphosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fbp in Genome Data Viewer
    Location:
    38A2-38A3; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19761587..19764136, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19761587..19764136, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dihydrouridine synthase 3 Neighboring gene brain-specific homeobox Neighboring gene Cd GTPase activating protein-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Listeria monocytogenes infection causes metabolic shifts in Drosophila melanogaster. Chambers MC, et al. PLoS One, 2012. PMID 23272066, Free PMC Article
    2. Organically grown food provides health benefits to Drosophila melanogaster. Chhabra R, et al. PLoS One, 2013. PMID 23326371, Free PMC Article
    3. Fructose-1,6-bisphosphatase genes in animals. Tillmann H, et al. Gene, 2002 May 29. PMID 12095679
    4. Honeybee queen mandibular pheromone induces a starvation response in Drosophila melanogaster. Lovegrove MR, et al. Insect Biochem Mol Biol, 2023 Mar. PMID 36657589
    5. Neuronal Gluconeogenesis Regulates Systemic Glucose Homeostasis in Drosophila melanogaster. Miyamoto T, et al. Curr Biol, 2019 Apr 22. PMID 30930040

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c19763048-19762862 mobile_element_type = transposon:pogo{}421

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose 1,6-bisphosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose 1,6-bisphosphate 1-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 6-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fructose-1,6-bisphosphatase
    Names
    CG31692-PA
    CG31692-PC
    CG31692-PD
    CG31692-PF
    fbp-PA
    fbp-PC
    fbp-PD
    fbp-PF
    NP_001286090.1
    NP_001286091.1
    NP_610001.1
    NP_724223.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19761587..19764136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299161.1 → NP_001286090.1  fructose-1,6-bisphosphatase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286090.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JES1
      Conserved Domains (1) summary
      cd00354
      Location:7 → 321
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

    2. NM_136157.3 → NP_610001.1  fructose-1,6-bisphosphatase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610001.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KT33, Q9VIS3
      Related
      FBpp0080853
      Conserved Domains (1) summary
      cd00354
      Location:19 → 333
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

    3. NM_001299162.1 → NP_001286091.1  fructose-1,6-bisphosphatase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286091.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JES1
      Conserved Domains (1) summary
      cd00354
      Location:7 → 321
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

    4. NM_165314.2 → NP_724223.4  fructose-1,6-bisphosphatase, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0U1RVK6, C6SV43
      Conserved Domains (1) summary
      cd00354
      Location:28 → 342
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0U1RVK6 A0A0U1RVK6
    Q9VIS3 Q9VIS3
    X2JES1 X2JES1

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