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    ninaB neither inactivation nor afterpotential B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41678, updated on 9-Dec-2024

    Summary

    Official Symbol
    ninaBprovided by FlyBase
    Official Full Name
    neither inactivation nor afterpotential Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002937
    Locus tag
    Dmel_CG9347
    See related
    AllianceGenome:FB:FBgn0002937
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0148162.1; anon-WO0148163.1; beta-diox; CG9347; Dmel\CG9347; DRPE65; RPE65
    Summary
    Enables carotenoid isomerooxygenase activity. Involved in isoprenoid metabolic process; phototransduction; and rhodopsin biosynthetic process. Is expressed in several structures, including Bolwig organ primordium; adult brain; adult head; photoreceptor; and retina. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to several human genes including BCO1 (beta-carotene oxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See ninaB in Genome Data Viewer
    Location:
    87F11-87F11; 3-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13700565..13703164)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9526287..9528886)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene oocyte maintenance defects Neighboring gene falafel Neighboring gene uncharacterized protein Neighboring gene flyers-cup Neighboring gene Adenosine deaminase-related growth factor D Neighboring gene Adenosine deaminase-related growth factor C Neighboring gene Arginine phosphatase

    Genomic regions, transcripts, and products

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in carotene catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in carotene metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phototransduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in phototransduction, UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phototransduction, visible light IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinal metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in rhodopsin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in rhodopsin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vitamin A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vitamin A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vitamin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    neither inactivation nor afterpotential B
    Names
    CG9347-PA
    beta-carotene dioxygenase
    ninaB-PA
    NP_650307.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13700565..13703164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142050.3NP_650307.2  neither inactivation nor afterpotential B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650307.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VFS2
      UniProtKB/TrEMBL
      Q9NKW9
      Related
      FBpp0082288
      Conserved Domains (1) summary
      pfam03055
      Location:52617
      RPE65; Retinal pigment epithelial membrane protein