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    Cyp40 Cyclophilin 40 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39121, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp40provided by FlyBase
    Official Full Name
    Cyclophilin 40provided by FlyBase
    Primary source
    FLYBASE:FBgn0036020
    Locus tag
    Dmel_CG8336
    See related
    AllianceGenome:FB:FBgn0036020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8336; Dmel\CG8336
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in RISC complex assembly. Acts upstream of with a positive effect on spermatogenesis. Part of protein folding chaperone complex. Is expressed in adult head; organism; spermatogonium; and testis. Orthologous to human PPID (peptidylprolyl isomerase D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp40 in Genome Data Viewer
    Location:
    67C2-67C3; 3-31 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9628676..9631795)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9621776..9624895)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Laminin B2 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 67b Neighboring gene furry Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Odorant receptor polymorphisms and natural variation in olfactory behavior in Drosophila melanogaster. Rollmann SM, et al. Genetics, 2010 Oct. PMID 20628035, Free PMC Article
    2. miRNA/siRNA-directed pathway to produce noncoding piRNAs from endogenous protein-coding regions ensures Drosophila spermatogenesis. Iki T, et al. Sci Adv, 2023 Jul 21. PMID 37467338, Free PMC Article
    3. Modulation of Ago2 Loading by Cyclophilin 40 Endows a Unique Repertoire of Functional miRNAs during Sperm Maturation in Drosophila. Iki T, et al. Cell Rep, 2020 Nov 10. PMID 33176138
    4. Dynamics of nuclear matrix proteome during embryonic development in Drosophila melanogaster. Varma P, et al. J Biosci, 2011 Aug. PMID 21799256
    5. Selection for cold resistance alters gene transcript levels in Drosophila melanogaster. Telonis-Scott M, et al. J Insect Physiol, 2009 Jun. PMID 19232407

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RISC complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piRNA-mediated gene silencing by mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_positive_effect spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein folding chaperone complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclophilin 40
    Names
    CG8336-PA
    CG8336-PB
    CG8336-PC
    CG8336-PD
    Cyp40-PA
    Cyp40-PB
    Cyp40-PC
    Cyp40-PD
    NP_001261636.1
    NP_648338.1
    NP_729517.1
    NP_729518.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9628676..9631795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168354.2 → NP_729517.1  cyclophilin 40, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729517.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VT21
      Related
      FBpp0076113
      Conserved Domains (4) summary
      sd00006
      Location:285 → 315
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:320 → 353
      TPR_1; Tetratricopeptide repeat
      pfam14559
      Location:300 → 369
      TPR_19; Tetratricopeptide repeat
      cl00197
      Location:15 → 181
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    2. NM_140081.3 → NP_648338.1  cyclophilin 40, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648338.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VT21
      Related
      FBpp0076114
      Conserved Domains (4) summary
      sd00006
      Location:285 → 315
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:320 → 353
      TPR_1; Tetratricopeptide repeat
      pfam14559
      Location:300 → 369
      TPR_19; Tetratricopeptide repeat
      cl00197
      Location:15 → 181
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    3. NM_168355.3 → NP_729518.1  cyclophilin 40, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729518.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VT21
      Related
      FBpp0076115
      Conserved Domains (4) summary
      sd00006
      Location:285 → 315
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:320 → 353
      TPR_1; Tetratricopeptide repeat
      pfam14559
      Location:300 → 369
      TPR_19; Tetratricopeptide repeat
      cl00197
      Location:15 → 181
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    4. NM_001274707.1 → NP_001261636.1  cyclophilin 40, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261636.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VT21
      Conserved Domains (4) summary
      sd00006
      Location:285 → 315
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:320 → 353
      TPR_1; Tetratricopeptide repeat
      pfam14559
      Location:300 → 369
      TPR_19; Tetratricopeptide repeat
      cl00197
      Location:15 → 181
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VT21 Q9VT21

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