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    CG31445 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326140, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG31445provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051445
    Locus tag
    Dmel_CG31445
    See related
    AllianceGenome:FB:FBgn0051445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11955; Dmel\CG31445
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head. Orthologous to several human genes including ANPEP (alanyl aminopeptidase, membrane). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG31445 in Genome Data Viewer
    Location:
    99A1-99A4; 3-98 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29240580..29244827, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25066302..25070549, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene SP1029 Neighboring gene string

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115
    2. Su(z)2 antagonizes auto-repression of Myc in Drosophila, increasing Myc levels and subsequent trans-activation. Khan A, et al. PLoS One, 2009. PMID 19333393, Free PMC Article
    3. Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila. Ma Z, et al. Elife, 2024 Sep 10. PMID 39255019, Free PMC Article
    4. Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila. Kuuluvainen E, et al. J Biol Chem, 2014 Jun 6. PMID 24778181, Free PMC Article
    5. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31445-PA
    CG31445-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29240580..29244827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276135.1 → NP_001263064.1  uncharacterized protein Dmel_CG31445, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263064.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SR0
      Conserved Domains (3) summary
      cd09601
      Location:43 → 497
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:28 → 426
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:578 → 904
      ERAP1_C; ERAP1-like C-terminal domain

    2. NM_143432.3 → NP_651689.1  uncharacterized protein Dmel_CG31445, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651689.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SR0
      Related
      FBpp0084770
      Conserved Domains (3) summary
      cd09601
      Location:43 → 497
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:28 → 426
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:578 → 904
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SR0 Q95SR0

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