rdgB retinal degeneration B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rdgBprovided by FlyBase
Official Full Name: retinal degeneration Bprovided by FlyBase
Primary source: FLYBASE:FBgn0003218
Locus tag: Dmel_CG11111
See related: AllianceGenome:FB:FBgn0003218
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11111; Dmel\CG11111; DrdgB; DrdgBalpha; hypoF; ota1; rdbB(ota1); RdgB; RDGB; rdgBalpha; RdgBalpha; RDGBalpha; x36
Summary: Enables phospholipid binding activity and phospholipid transporter activity. Involved in several processes, including G protein-coupled opsin signaling pathway; negative regulation of opsin-mediated signaling pathway; and sensory perception of smell. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; female germline stem cell; larval brain; larval central nervous system; and terminal filament. Orthologous to several human genes including PITPNM1 (phosphatidylinositol transfer protein membrane associated 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 12C1-12C4; 1-46 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13762752..13779488)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13656785..13673521)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

membrane contact site localization of RDGBalpha depends on the interaction of its FFAT motif with dVAP-A
Title: RDGBα localization and function at membrane contact sites is regulated by FFAT-VAP interactions.
Thus RDGB couples the turnover of both PtdIns and PtdOH, key lipid intermediates during G-protein-coupled PtdIns(4,5)P2 turnover.
Title: RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction.
Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis.
Title: Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidic acid transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylcholine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol transfer activity	NAS Non-traceable Author Statement more info	PubMed
enables phospholipid transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled opsin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in phosphatidylinositol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid transport	IEA Inferred from Electronic Annotation more info
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	TAS Traceable Author Statement more info	PubMed
involved_in phototransduction, visible light	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in subrhabdomeral cisterna	NAS Non-traceable Author Statement more info	PubMed
located_in subrhabdomeral cisterna	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: retinal degeneration B

Names: CG11111-PA; CG11111-PB; CG11111-PC; CG11111-PD; CG11111-PE; CG11111-PF; CG11111-PG; CG11111-PH; CG11111-PI; CG11111-PJ; CG11111-PK; rdgB-PA; rdgB-PB; rdgB-PC; rdgB-PD; rdgB-PE; rdgB-PF; rdgB-PG; rdgB-PH; rdgB-PI; rdgB-PJ; rdgB-PK; receptor degeneration B; receptor-degeneration-II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13762752..13779488

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272605.2 → NP_001259534.1 retinal degeneration B, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259534.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PJM8

Conserved Domains (3) summary

cd08889
Location:1 → 268

SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)

smart00775
Location:1072 → 1203

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:746 → 924

DDHD; DDHD domain
NM_001014741.3 → NP_001014741.1 retinal degeneration B, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014741.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4E8, O02434, P43125, Q6NP01, Q961R2, Q9VY88

Conserved Domains (3) summary

cd08889
Location:1 → 268

SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)

smart00775
Location:1059 → 1190

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:733 → 911

DDHD; DDHD domain
NM_167382.3 → NP_727733.1 retinal degeneration B, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727733.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4E8, O02434, P43125, Q6NP01, Q961R2, Q9VY88

Related

FBpp0073653

Conserved Domains (3) summary

cd08889
Location:1 → 268

SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)

smart00775
Location:1059 → 1190

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:733 → 911

DDHD; DDHD domain
NM_001014740.2 → NP_001014740.1 retinal degeneration B, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014740.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4E8, O02434, P43125, Q6NP01, Q961R2, Q9VY88

Conserved Domains (3) summary

cd08889
Location:1 → 268

SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)

smart00775
Location:1059 → 1190

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:733 → 911

DDHD; DDHD domain
NM_001169280.3 → NP_001162751.1 retinal degeneration B, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162751.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJK6

Conserved Domains (3) summary

cd08889
Location:1 → 268

SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)

smart00775
Location:1072 → 1203

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:746 → 924

DDHD; DDHD domain
NM_001169278.3 → NP_001162749.1 retinal degeneration B, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162749.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJK7

Conserved Domains (3) summary

cd08889
Location:1 → 268

SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)

smart00775
Location:1059 → 1190

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:733 → 911

DDHD; DDHD domain
NM_001169279.3 → NP_001162750.1 retinal degeneration B, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162750.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJK8

Conserved Domains (3) summary

cd08889
Location:1 → 268

SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)

smart00775
Location:1046 → 1177

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:733 → 898

DDHD; DDHD domain
NM_001169277.2 → NP_001162748.1 retinal degeneration B, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162748.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJK9

Conserved Domains (3) summary

cd08889
Location:1 → 268

SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)

smart00775
Location:1059 → 1190

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:733 → 911

DDHD; DDHD domain
NM_001272606.1 → NP_001259535.1 retinal degeneration B, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259535.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEJ5

Conserved Domains (3) summary

cd08889
Location:1 → 268

SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)

smart00775
Location:1072 → 1203

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:746 → 924

DDHD; DDHD domain
NM_001298300.1 → NP_001285229.1 retinal degeneration B, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285229.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JF93

Conserved Domains (3) summary

cd08889
Location:1 → 268

SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)

smart00775
Location:1059 → 1190

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:733 → 911

DDHD; DDHD domain
NM_078594.3 → NP_511149.2 retinal degeneration B, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511149.2

Status: REVIEWED

UniProtKB/TrEMBL

E1JJK7

Related

FBpp0073654

Conserved Domains (3) summary

cd08889
Location:1 → 268

SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)

smart00775
Location:1059 → 1190

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:733 → 911

DDHD; DDHD domain