Irk2 Inwardly rectifying potassium channel 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Irk2provided by FlyBase
Official Full Name: Inwardly rectifying potassium channel 2provided by FlyBase
Primary source: FLYBASE:FBgn0039081
Locus tag: Dmel_CG4370
See related: AllianceGenome:FB:FBgn0039081
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10180; CG4370; dIRK-2; dKir; dKirII; Dmel\CG4370; irk2; Kir2
Summary: Enables inward rectifier potassium channel activity. Involved in potassium ion transport; regulation of membrane potential; and wing disc development. Located in membrane. Is expressed in adult Malpighian tubule principal cell; adult head; embryonic large intestine; embryonic small intestine; and epithelial tube. Human ortholog(s) of this gene implicated in alcohol use disorder; glucose metabolism disease (multiple); and heroin dependence. Orthologous to several human genes including KCNJ9 (potassium inwardly rectifying channel subfamily J member 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23513617..23519445, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19339339..19345167, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: CG4370-PA; CG4370-PB; CG4370-PC; CG4370-PD; Irk2-PA; Irk2-PB; Irk2-PC; Irk2-PD

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