Rpt5 Regulatory particle triple-A ATPase 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rpt5provided by FlyBase
Official Full Name: Regulatory particle triple-A ATPase 5provided by FlyBase
Primary source: FLYBASE:FBgn0028684
Locus tag: Dmel_CG10370
See related: AllianceGenome:FB:FBgn0028684
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0153538.10; anon-WO0153538.8; anon-WO0153538.9; BcDNA.GH12068; BcDNA:GH12068; CG10370; Dmel\CG10370; DmTBP-1; Dm_Rpt5a; Dm_Rpt5b; dRpt5; l(3)04210; p50; Pros26S; Pros26S-RS6A; RPT5; S6'; tbp-1; Tbp-1; TBP-1; Tbp1
Summary: Predicted to enable proteasome-activating activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm. Part of proteasome regulatory particle, base subcomplex. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Used to study syndromic intellectual disability. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 95B1-95B1; 3-80 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23752876..23754623)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19578598..19580345)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSMC3 proteasome subunit variants are associated with neurodevelopmental delay and type I interferon production.
Title: PSMC3 proteasome subunit variants are associated with neurodevelopmental delay and type I interferon production.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1710 (e-PCR)
- UniSTS:20198

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome-activating activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
part_of proteasome regulatory particle	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, base subcomplex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, base subcomplex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: regulatory particle triple-A ATPase 5

Names: CG10370-PA; Rpt5-PA; Tat-binding protein-1; proteasome 26S regulatory subunit 6A

NP_524464.1

EC 5.6.1.5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

23752876..23754623

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079740.4 → NP_524464.1 regulatory particle triple-A ATPase 5 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524464.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9V3V6, Q9XZC3

Related

FBpp0083843

Conserved Domains (1) summary

COG1222
Location:33 → 421

RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]