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    GstE1 Glutathione S transferase E1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GstE1provided by FlyBase
    Official Full Name
    Glutathione S transferase E1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034335
    Locus tag
    Dmel_CG5164
    See related
    AllianceGenome:FB:FBgn0034335
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5164; CT16545; Dmel\CG5164; DmGST-3; DmGSTE1; DmGSTE1-1; gst-3; Gst-3; GST-3; GST-E1; Gst-theta 55F; Gst3; GST3; Gst55F; gste1; gstE1; GSTE1
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process and response to heat. Predicted to be located in cytoplasm. Is expressed in adult head; organism; stretch follicle cell; and unfertilized egg. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstE1 in Genome Data Viewer
    Location:
    55C6-55C6; 2-85 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18398393..18399223)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14285898..14286728)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Bomanin Short 6 Neighboring gene Imaginal disc growth factor 5 Neighboring gene Glutathione S transferase E10 Neighboring gene Glutathione S transferase E2 Neighboring gene Glutathione S transferase E3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a new theta-class glutathione-S-transferase (GST) gene, gst-3, from Drosophila melanogaster. Singh M, et al. Gene, 2000 Apr 18. PMID 10773456
    2. Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome. Li C, et al. Nat Commun, 2017 Nov 2. PMID 29097652, Free PMC Article
    3. Data on the expression of GSTE1 and GSTE7 in Drosophila chemosensory organs after isothiocyanate exposure. Fraichard S, et al. Data Brief, 2018 Oct. PMID 30148193, Free PMC Article
    4. Yin and Yang of mitochondrial ROS in Drosophila. Towarnicki SG, et al. J Insect Physiol, 2020 Apr. PMID 32045573
    5. Editor's Highlight: Glutathione S-Transferase Activity Moderates Methylmercury Toxicity During Development in Drosophila. Vorojeikina D, et al. Toxicol Sci, 2017 May 1. PMID 28184905, Free PMC Article

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase E1
    Names
    CG5164-PA
    Glutathione-S-transferase E1
    GstE1-PA
    glutathione S-transferase
    glutathione-S-transferase
    NP_611323.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18398393..18399223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137479.3 → NP_611323.1  glutathione S transferase E1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611323.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KK90
      Related
      FBpp0085850
      Conserved Domains (3) summary
      cd03177
      Location:94 → 210
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:8 → 197
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:6 → 79
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KK90 Q7KK90

    Gene LinkOut

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