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    CG8774 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8774provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038136
    Locus tag
    Dmel_CG8774
    See related
    AllianceGenome:FB:FBgn0038136
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8774
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head. Orthologous to human ENPEP (glutamyl aminopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8774 in Genome Data Viewer
    Location:
    87E4-87E5; 3-53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13298768..13302334)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9124490..9128056)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene wnt inhibitor of Dorsal Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115
    2. Differential evolutionary wiring of the tyrosine kinase Btk. Nawaz HM, et al. PLoS One, 2012. PMID 22574122, Free PMC Article
    3. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540
    4. Dynamics of Dark-Fly Genome Under Environmental Selections. Izutsu M, et al. G3 (Bethesda), 2015 Dec 4. PMID 26637434, Free PMC Article
    5. Drosophila microbiota modulates host metabolic gene expression via IMD/NF-κB signaling. Erkosar B, et al. PLoS One, 2014. PMID 24733183, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8774-PA
    CG8774-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13298768..13302334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169502.2 → NP_731785.1  uncharacterized protein Dmel_CG8774, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHC5, Q9VFW8
      Related
      FBpp0082208
      Conserved Domains (3) summary
      cd09601
      Location:18 → 461
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:10 → 397
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:536 → 853
      ERAP1_C; ERAP1-like C-terminal domain

    2. NM_142017.3 → NP_650274.2  uncharacterized protein Dmel_CG8774, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650274.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNG9, Q9VFW9
      Related
      FBpp0082209
      Conserved Domains (3) summary
      cd09601
      Location:75 → 518
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:67 → 454
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:593 → 910
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IHC5 Q8IHC5
    Q95TZ5 Q95TZ5
    Q9VFW8 Q9VFW8
    Q9VFW9 Q9VFW9

    Gene LinkOut

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