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    crim crimpled [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39321, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crimprovided by FlyBase
    Official Full Name
    crimpledprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036198
    Locus tag
    Dmel_CG6038
    See related
    AllianceGenome:FB:FBgn0036198
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6038; Crim; Dmel\CG6038
    Summary
    Involved in liquid clearance, open tracheal system; regulation of tube size, open tracheal system; and septate junction assembly. Located in septate junction. Is expressed in several structures, including adult head; dorsal epidermis primordium; embryonic dorsal epidermis; embryonic epipharynx; and embryonic hindgut. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See crim in Genome Data Viewer
    Location:
    68D2-68D3; 3-36 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11710507..11711386, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11703607..11704486, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, intermediate chain 2 Neighboring gene uncharacterized protein Neighboring gene Coiled-coil domain containing 56 Neighboring gene Mitochondrial Transcription Factor B1 Neighboring gene uncharacterized protein Neighboring gene bmcp

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The claudin Megatrachea protein complex. Jaspers MH, et al. J Biol Chem, 2012 Oct 26. PMID 22930751, Free PMC Article
    2. Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large. Oshima K, et al. J Cell Sci, 2011 Aug 15. PMID 21807950, Free PMC Article
    3. Isolation of microRNA targets by miRNP immunopurification. Easow G, et al. RNA, 2007 Aug. PMID 17592038, Free PMC Article
    4. The Drosophila septate junctions beyond barrier function: Review of the literature, prediction of human orthologs of the SJ-related proteins and identification of protein domain families. Rouka E, et al. Acta Physiol (Oxf), 2021 Jan. PMID 32603029
    5. Crooked, coiled and crimpled are three Ly6-like proteins required for proper localization of septate junction components. Nilton A, et al. Development, 2010 Jul. PMID 20570942, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic transmission, cholinergic IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sleep IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    crimpled
    Names
    CG6038-PA
    crim-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11710507..11711386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140243.4 → NP_648500.1  crimpled [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648500.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTM6
      Related
      FBpp0075854
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTM6 Q9VTM6
    Q9VTM6.1

    Gene LinkOut

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