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    Pef Peflin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36111, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pefprovided by FlyBase
    Official Full Name
    Peflinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033529
    Locus tag
    Dmel_CG17765
    See related
    AllianceGenome:FB:FBgn0033529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17765; Dmel\CG17765; pef; peflin
    Summary
    Predicted to enable calcium ion binding activity. Acts upstream of with a positive effect on retrograde trans-synaptic signaling. Is active in postsynaptic cytosol. Is expressed in several structures, including adult heart; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and mesoderm. Orthologous to human PEF1 (penta-EF-hand domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pef in Genome Data Viewer
    Location:
    47A11-47A11; 2-62 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10480163..10481886)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6367668..6369391)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45134 Neighboring gene withered Neighboring gene pre-lola-G Neighboring gene translin Neighboring gene longitudinals lacking Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling. Kikuma K, et al. Nat Commun, 2019 Jul 5. PMID 31278365, Free PMC Article
    2. Functional characterization of Drosophila Translin and Trax. Claussen M, et al. Genetics, 2006 Nov. PMID 17028328, Free PMC Article
    3. Synaptic homeostats: latent plasticity revealed at the Drosophila neuromuscular junction. Goel P, et al. Cell Mol Life Sci, 2021 Apr. PMID 33449150, Free PMC Article
    4. Mutations of the withered (whd) gene in Drosophila melanogaster confer hypersensitivity to oxidative stress and are lesions of the carnitine palmitoyltransferase I (CPT I) gene. Strub BR, et al. Genome, 2008 Jun. PMID 18521119
    5. Identification of genes expressed during Drosophila melanogaster gastrulation by using subtractive hybridization. González-Agüero M, et al. Gene, 2005 Jan 31. PMID 15716118

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect retrograde trans-synaptic signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in postsynaptic cytosol IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peflin
    Names
    CG17765-PA
    Pef-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10480163..10481886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136748.4 → NP_610592.1  peflin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610592.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2L7
      Related
      FBpp0087367
      Conserved Domains (3) summary
      COG5126
      Location:26 → 162
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:39 → 92
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:105 → 159
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K2L7 Q7K2L7

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