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    Kots Kotsubu [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kotsprovided by FlyBase
    Official Full Name
    Kotsubuprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038191
    Locus tag
    Dmel_CG9925
    See related
    AllianceGenome:FB:FBgn0038191
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9925; Dmel\CG9925; kots
    Summary
    Involved in secondary piRNA processing. Located in P granule. Is expressed in several structures, including egg chamber; fat body/gonad primordium; germarium; germline cell; and gonad. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Kots in Genome Data Viewer
    Location:
    88A3-88A3; 3-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13960712..13964174, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9786434..9789896, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene stable intronic sequence RNA CR46363 Neighboring gene Inositol polyphosphate 1-phosphatase Neighboring gene Origin recognition complex subunit 2 Neighboring gene roadkill

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intron retention in the Drosophila melanogaster Rieske Iron Sulphur Protein gene generated a new protein. Gontijo AM, et al. Nat Commun, 2011. PMID 21610726, Free PMC Article
    2. oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction. Kanke M, et al. RNA, 2015 Jun. PMID 25862242, Free PMC Article
    3. Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila. Hekmat-Scafe DS, et al. J Neurosci, 2006 Aug 30. PMID 16943550, Free PMC Article
    4. The Tudor Domain-Containing Protein, Kotsubu (CG9925), Localizes to the Nuage and Functions in piRNA Biogenesis in D. melanogaster. Lim LX, et al. Front Mol Biosci, 2022. PMID 35425810, Free PMC Article
    5. Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks. Chaouch A, et al. Mol Cell, 2021 Dec 2. PMID 34739871, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in P granule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of innate immune response HMP PubMed 
    involved_in secondary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transposable element silencing by mRNA destabilization IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kotsubu
    Names
    CG9925-PA
    Kots-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13960712..13964174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142067.3 → NP_650324.1  kotsubu [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650324.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3N7, Q9VFP5
      Related
      FBpp0082339
      Conserved Domains (3) summary
      cd04508
      Location:779 → 825
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:109 → 225
      TUDOR; Tudor domain
      pfam01753
      Location:9 → 44
      zf-MYND; MYND finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T3N7 Q8T3N7
    Q9VFP5 Q9VFP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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