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    Dhx15 DEAH-box helicase 15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhx15provided by FlyBase
    Official Full Name
    DEAH-box helicase 15provided by FlyBase
    Primary source
    FLYBASE:FBgn0033160
    Locus tag
    Dmel_CG11107
    See related
    AllianceGenome:FB:FBgn0033160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.18; cg11107; CG11107; clone 1.18; DHX15; Dmel\CG11107
    Summary
    Predicted to enable RNA binding activity and RNA helicase activity. Involved in positive regulation of p38MAPK cascade. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head; embryonic/larval midgut; gonad; and organism. Orthologous to human DHX15 (DEAH-box helicase 15). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dhx15 in Genome Data Viewer
    Location:
    43B2-43B2; 2-56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7387187..7391023)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3274692..3278528)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Down syndrome cell adhesion molecule 1 Neighboring gene antisense RNA:CR44071 Neighboring gene costa Neighboring gene antisense RNA:CR44201 Neighboring gene Gustatory receptor 43a Neighboring gene Glyoxalase 1 Neighboring gene uncharacterized protein Neighboring gene ELL-associated factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses. Mosallanejad K, et al. Sci Signal, 2014 Apr 29. PMID 24782566
    2. dTrmt10A impacts Hsp70 chaperone m(6)A levels and the stress response in the Drosophila brain. Perlegos AE, et al. Sci Rep, 2023 Dec 28. PMID 38155219, Free PMC Article
    3. Tracing the origin of the compensasome: evolutionary history of DEAH helicase and MYST acetyltransferase gene families. Sanjuán R, et al. Mol Biol Evol, 2001 Mar. PMID 11230534
    4. Genes involved in Drosophila glutamate receptor expression and localization. Liebl FL, et al. BMC Neurosci, 2005 Jun 28. PMID 15985179, Free PMC Article
    5. SSCP analysis of cDNA markers provides a dense linkage map of the Aedes aegypti genome. Fulton RE, et al. Genetics, 2001 Jun. PMID 11404335, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of p38MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DEAH-box helicase 15
    Names
    CG11107-PA
    CG11107-PB
    DHX15 ortholog
    Dhx15-PA
    Dhx15-PB
    NP_001260766.1
    NP_610269.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7387187..7391023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136425.3 → NP_610269.1  DEAH-box helicase 15, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610269.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K3M5
      Related
      FBpp0088040
      Conserved Domains (6) summary
      smart00490
      Location:315 → 408
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:67 → 255
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:478 → 561
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:91 → 228
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cl22853
      Location:50 → 102
      Motor_domain; Myosin and Kinesin motor domain
      pfam07717
      Location:595 → 698
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    2. NM_001273837.1 → NP_001260766.1  DEAH-box helicase 15, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260766.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K3M5
      Conserved Domains (6) summary
      smart00490
      Location:315 → 408
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:67 → 255
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:478 → 561
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:91 → 228
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cl22853
      Location:50 → 102
      Motor_domain; Myosin and Kinesin motor domain
      pfam07717
      Location:595 → 698
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3M5.1 Q7K3M5

    Gene LinkOut

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