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    Mybbp1A MYB binding protein 1a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31010, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mybbp1Aprovided by FlyBase
    Official Full Name
    MYB binding protein 1aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001341
    Locus tag
    Dmel_CG6189
    See related
    AllianceGenome:FB:FBgn0001341
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6189; Dmel\CG6189; dMYBBP1A; EG:115C2.2; HM-419; HM-52; l(1)1Bi; l(1)Bi; l(1)lBi; mybbp1a
    Summary
    Predicted to enable sequence-specific DNA binding activity and transcription corepressor activity. Involved in positive regulation of ribosome biogenesis and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to be active in nucleolus. Orthologous to human MYBBP1A (MYB binding protein 1a). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mybbp1A in Genome Data Viewer
    Location:
    1B12-1B12; 1-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (629773..633633)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (523806..527666)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45475 Neighboring gene Histone H4 transcription factor Neighboring gene Ribosomal protein L36 Neighboring gene mir-9372 stem loop Neighboring gene Death related ced-3/Nedd2-like caspase Neighboring gene suppressor of sable

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila. Chen P, et al. Dev Biol, 1998 Sep 15. PMID 9740659
    2. PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression. Liu Y, et al. Dev Cell, 2017 Oct 23. PMID 29065309
    3. The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. Leulier F, et al. EMBO Rep, 2000 Oct. PMID 11269502, Free PMC Article
    4. Mapping a mutator, mu2, which increases the frequency of terminal deletions in Drosophila melanogaster. Wang M, et al. Mol Gen Genet, 1994 Dec 1. PMID 7808410
    5. Molecular and genetic organization of the suppressor of sable and minute (1) 1B region in Drosophila melanogaster. Voelker RA, et al. Genetics, 1989 Jul. PMID 2503417, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of ribosome biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MYB binding protein 1a
    Names
    CG6189-PA
    Mybbp1A-PA
    lethal (1) 1Bi

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      629773..633633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057245.3 → NP_476593.2  MYB binding protein 1a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476593.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5BIF7, Q8MRJ3, Q9W5E4
      UniProtKB/TrEMBL
      Q24034
      Related
      FBpp0070114
      Conserved Domains (1) summary
      pfam04931
      Location:115 → 854
      DNA_pol_phi; DNA polymerase phi
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24034 Q24034
    Q9W5E4.1 Q9W5E4

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