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    sxc super sex combs [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35486, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sxcprovided by FlyBase
    Official Full Name
    super sex combsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261403
    Locus tag
    Dmel_CG10392
    See related
    AllianceGenome:FB:FBgn0261403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH04245; CG10392; Dmel\CG10392; DmOGT; dO-GnT; l(2)02637; l(2)NC130; ogt; Ogt; OGT; P1201; Sxc; SXC; sxc/Ogt
    Summary
    Enables protein O-acetylglucosaminyltransferase activity. Involved in several processes, including locomotor rhythm; positive regulation of fibroblast growth factor receptor signaling pathway; and protein O-linked glycosylation. Is expressed in adult head and organism. Used to study non-syndromic X-linked intellectual disability 106. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sxc in Genome Data Viewer
    Location:
    41E4-41E5; 2-55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5307288..5329555)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1194793..1217060)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR41443 Neighboring gene d4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Intraflagellar transport 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development. Mariappa D, et al. Biochem J, 2015 Sep 1. PMID 26348912, Free PMC Article
    2. A Chemical Genetic Method for Monitoring Genome-Wide Dynamics of O-GlcNAc Turnover on Chromatin-Associated Proteins. Liu TW, et al. ACS Cent Sci, 2019 Apr 24. PMID 31041386, Free PMC Article
    3. A gene that regulates the bithorax complex differentially in larval and adult cells of Drosophila. Ingham PW. Cell, 1984 Jul. PMID 6430566
    4. The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha. Jínek M, et al. Nat Struct Mol Biol, 2004 Oct. PMID 15361863
    5. Adipose Tissue Exosome circ_sxc Mediates the Modulatory of Adiposomes on Brain Aging by Inhibiting Brain dme-miR-87-3p. Li Q, et al. Mol Neurobiol, 2024 Jan. PMID 37597108

    See all (137) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 5309114-5311497 mobile_element_type = transposon:1360{}644
    • Loc: 5311605-5311882 mobile_element_type = transposon:FB{}3670
    • Loc: 5313143-5315274 mobile_element_type = transposon:Rt1b{}3595
    • Loc: 5315424-5315718 mobile_element_type = transposon:I{}3122
    • Loc: 5319716-5319832 mobile_element_type = transposon:Transpac{}3603
    • Loc: 5320913-5321012 mobile_element_type = transposon:INE-1{}3176
    • Loc: 5321034-5321102 mobile_element_type = transposon:INE-1{}3178
    • Loc: 5322624-5322718 mobile_element_type = transposon:INE-1{}3179
    • Loc: 5323463-5323518 mobile_element_type = transposon:ninja-Dsim-like{}3776
    • Loc: 5323910-5324185 mobile_element_type = transposon:INE-1{}3180
    • Loc: 5324219-5324324 mobile_element_type = transposon:INE-1{}3182
    • Loc: 5328095-5328420 mobile_element_type = transposon:INE-1{}3195

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein O-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein O-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein O-acetylglucosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycoprotein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    super sex combs
    Names
    CG10392-PA
    CG10392-PB
    CG10392-PC
    O-GlcNAc transferase
    O-glycosyltransferase
    O-linked N-acetylglucosamine transferase
    lethal (2) NC130
    sxc-PA
    sxc-PB
    sxc-PC
    NP_523620.1
    NP_724406.1
    NP_724407.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5307288..5329555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165427.2 → NP_724407.1  super sex combs, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724407.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJA9, Q9Y148
      Related
      FBpp0085422
      Conserved Domains (8) summary
      COG0457
      Location:233 → 490
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:255 → 282
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:118 → 151
      TPR_1; Tetratricopeptide repeat
      pfam13374
      Location:356 → 385
      TPR_10; Tetratricopeptide repeat
      pfam13414
      Location:118 → 183
      TPR_11; TPR repeat
      pfam13424
      Location:182 → 252
      TPR_12; Tetratricopeptide repeat
      pfam13431
      Location:310 → 342
      TPR_17; Tetratricopeptide repeat
      pfam13844
      Location:584 → 1044
      Glyco_transf_41; Glycosyl transferase family 41

    2. NM_165426.2 → NP_724406.1  super sex combs, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724406.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJA9, Q9Y148
      Related
      FBpp0085421
      Conserved Domains (8) summary
      COG0457
      Location:233 → 490
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:255 → 282
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:118 → 151
      TPR_1; Tetratricopeptide repeat
      pfam13374
      Location:356 → 385
      TPR_10; Tetratricopeptide repeat
      pfam13414
      Location:118 → 183
      TPR_11; TPR repeat
      pfam13424
      Location:182 → 252
      TPR_12; Tetratricopeptide repeat
      pfam13431
      Location:310 → 342
      TPR_17; Tetratricopeptide repeat
      pfam13844
      Location:584 → 1044
      Glyco_transf_41; Glycosyl transferase family 41

    3. NM_078896.3 → NP_523620.1  super sex combs, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523620.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJA9, Q9Y148
      Related
      FBpp0085420
      Conserved Domains (8) summary
      COG0457
      Location:233 → 490
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:255 → 282
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:118 → 151
      TPR_1; Tetratricopeptide repeat
      pfam13374
      Location:356 → 385
      TPR_10; Tetratricopeptide repeat
      pfam13414
      Location:118 → 183
      TPR_11; TPR repeat
      pfam13424
      Location:182 → 252
      TPR_12; Tetratricopeptide repeat
      pfam13431
      Location:310 → 342
      TPR_17; Tetratricopeptide repeat
      pfam13844
      Location:584 → 1044
      Glyco_transf_41; Glycosyl transferase family 41
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KJA9 Q7KJA9
    Q95RP9 Q95RP9
    Q9Y148 Q9Y148

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