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    Dp1 Dodeca-satellite-binding protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37116, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dp1provided by FlyBase
    Official Full Name
    Dodeca-satellite-binding protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027835
    Locus tag
    Dmel_CG5170
    See related
    AllianceGenome:FB:FBgn0027835
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.516; anon-WO0172774.168; BcDNA:LD21383; BcDNA:LD21677; CG5170; ddp1; DDP1; Dmel\CG5170; DP1
    Summary
    Enables mRNA 3'-UTR binding activity; satellite DNA binding activity; and single-stranded DNA binding activity. Involved in chromosome condensation; chromosome segregation; and regulation of gene expression. Located in heterochromatin; nucleus; and polytene chromosome chromocenter. Part of ribonucleoprotein complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and mesoderm. Used to study prostate cancer. Orthologous to human HDLBP (high density lipoprotein binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dp1 in Genome Data Viewer
    Location:
    55C8-55C8; 2-85 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18412027..18421124)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14299532..14308629)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase E8 Neighboring gene Glutathione S transferase E9 Neighboring gene immune deficiency Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class O Neighboring gene TRPL translocation defect 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DDP1, a heterochromatin-associated multi-KH-domain protein of Drosophila melanogaster, interacts specifically with centromeric satellite DNA sequences. Cortés A, et al. Mol Cell Biol, 2000 Jun. PMID 10805729, Free PMC Article
    2. RNAi-mediated depletion of the 15 KH domain protein, vigilin, induces death of dividing and non-dividing human cells but does not initially inhibit protein synthesis. Goolsby KM, et al. Nucleic Acids Res, 2003 Oct 1. PMID 14500828, Free PMC Article
    3. DDP1, a single-stranded nucleic acid-binding protein of Drosophila, associates with pericentric heterochromatin and is functionally homologous to the yeast Scp160p, which is involved in the control of cell ploidy. Cortés A, et al. EMBO J, 1999 Jul 1. PMID 10393197, Free PMC Article
    4. Analysing the contribution of nucleic acids to the structure and properties of centric heterochromatin. Cortés A, et al. Genetica, 2003 Mar. PMID 12723691
    5. Heterochromatin: RNA points the way. Birchler JA, et al. Curr Biol, 2004 Sep 21. PMID 15380087

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that DDP1 vastly localises to the cytoplasm, being largely excluded from the nucleus, and preferentially associates to RER and co-purifies with several ribosomal proteins.
      Title: Drosophila vigilin, DDP1, localises to the cytoplasm and associates to the rough endoplasmic reticulum.
    2. Three proteins (DDP1, Hrp48, and poly(A)-binding protein) are components of the HDE-binding complex and function in translational enhancement
      Title: A multiprotein complex that mediates translational enhancement in Drosophila.
    3. DDP1 binds single-stranded nucleic acids with high affinity and contributes to the structural and functional properties of heterochromatin.
      Title: Drosophila DDP1, a multi-KH-domain protein, contributes to centromeric silencing and chromosome segregation.
    4. Mutation or depletion of the Drosophila Vigilin, DDP1, leads to altered nuclear morphology and defects in heterochromatin and chromosome segregation.
      Title: Vigilins bind to promiscuously A-to-I-edited RNAs and are involved in the formation of heterochromatin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables satellite DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dodeca-satellite-binding protein 1
    Names
    CG5170-PA
    CG5170-PB
    CG5170-PD
    CG5170-PE
    CG5170-PF
    CG5170-PG
    CG5170-PH
    Dp1-PA
    Dp1-PB
    Dp1-PD
    Dp1-PE
    Dp1-PF
    Dp1-PG
    Dp1-PH
    dodeca satellite binding protein 1
    dodeca-satellite protein 1
    dodeca-satellite-binding protein 1
    drosophila dodeca-satellite-binding protein 1
    vigilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18412027..18421124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206163.2 → NP_995885.1  Dodeca-satellite-binding protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995885.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KN75, Q9U982
      Conserved Domains (1) summary
      cd02394
      Location:598 → 659
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

    2. NM_166280.2 → NP_725785.1  Dodeca-satellite-binding protein 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KN75, Q9U982
      Related
      FBpp0085860
      Conserved Domains (1) summary
      cd02394
      Location:598 → 659
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

    3. NM_206164.2 → NP_995886.1  Dodeca-satellite-binding protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995886.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KN75, Q9U982
      Conserved Domains (1) summary
      cd02394
      Location:598 → 659
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

    4. NM_166282.2 → NP_725787.1  Dodeca-satellite-binding protein 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725787.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KN75, Q9U982
      Related
      FBpp0085861
      Conserved Domains (1) summary
      cd02394
      Location:598 → 659
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

    5. NM_166281.2 → NP_725786.1  Dodeca-satellite-binding protein 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725786.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KN75, Q9U982
      Related
      FBpp0085862
      Conserved Domains (1) summary
      cd02394
      Location:598 → 659
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

    6. NM_001299644.1 → NP_001286573.1  Dodeca-satellite-binding protein 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KN75, Q9U982
      Conserved Domains (1) summary
      cd02394
      Location:598 → 659
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

    7. NM_079057.3 → NP_523781.2  Dodeca-satellite-binding protein 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523781.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KN75, Q9U982
      Related
      FBpp0309290
      Conserved Domains (1) summary
      cd02394
      Location:598 → 659
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KN75 Q7KN75
    Q7KN84 Q7KN84
    Q95T04 Q95T04
    Q9U982 Q9U982

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