Glyp Glycogen phosphorylase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Glypprovided by FlyBase
Official Full Name: Glycogen phosphorylaseprovided by FlyBase
Primary source: FLYBASE:FBgn0004507
Locus tag: Dmel_CG7254
See related: AllianceGenome:FB:FBgn0004507
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0257455.33; BcDNA:LD24485; CG7254; DGPH; Dmel\CG7254; Glp1; GLP1; glyP; GlyP; GP; l(2)k07918; PYGM
Summary: Enables glycogen phosphorylase activity; protein homodimerization activity; and pyridoxal phosphate binding activity. Involved in determination of adult lifespan; glycogen catabolic process; and insulin receptor signaling pathway. Located in cytosol. Is expressed in adult head; adult heart; larval somatic muscle cell; organism; and spermatozoon. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease V; glycogen storage disease VI; and lactic acidosis. Orthologous to several human genes including PYGM (glycogen phosphorylase, muscle associated). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 22C3-22D1; 2-5 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2130813..2137296)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2130813..2137296)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables glycogen phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycogen phosphorylase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycogen phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables glycogen phosphorylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycogen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of innate immune response	HMP more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glycogen phosphorylase

Names: CG7254-PA; CG7254-PB; Glyp-PA; Glyp-PB; glycogen phosphorylase b

NP_001027219.1

EC 2.4.1.1

NP_722762.1

EC 2.4.1.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

2130813..2137296

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164453.4 → NP_722762.1 glycogen phosphorylase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722762.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V467, Q9XTL9

UniProtKB/TrEMBL

A4UZZ4

Related

FBpp0077501

Conserved Domains (2) summary

cd04300
Location:29 → 828

GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...

TIGR02093
Location:32 → 828

P_ylase; glycogen/starch/alpha-glucan phosphorylases
NM_001032048.2 → NP_001027219.1 glycogen phosphorylase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027219.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V467, Q9XTL9

UniProtKB/TrEMBL

A4UZZ4

Conserved Domains (2) summary

cd04300
Location:29 → 828

GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...

TIGR02093
Location:32 → 828

P_ylase; glycogen/starch/alpha-glucan phosphorylases