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    Helz Helicase with zinc finger [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39613, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Helzprovided by FlyBase
    Official Full Name
    Helicase with zinc fingerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036451
    Locus tag
    Dmel_CG9425
    See related
    AllianceGenome:FB:FBgn0036451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9425; Dmel\CG9425; HELZ
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be active in P granule and cytosol. Is expressed in adult head. Orthologous to human HELZ (helicase with zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Helz in Genome Data Viewer
    Location:
    70F6-70F6; 3-42 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14789935..14801089)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14783035..14794189)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene brummer Neighboring gene Tudor domain containing 3 Neighboring gene NHP2 Neighboring gene giant nuclei

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. Hanet A, et al. Life Sci Alliance, 2019 Oct. PMID 31570513, Free PMC Article
    2. A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos. Kim YO, et al. Proc Natl Acad Sci U S A, 2004 Jan 6. PMID 14684833, Free PMC Article
    3. Genome-wide prediction of Polycomb/Trithorax response elements in Drosophila melanogaster. Ringrose L, et al. Dev Cell, 2003 Nov. PMID 14602076
    4. The Hippo signaling pathway interactome. Kwon Y, et al. Science, 2013 Nov 8. PMID 24114784, Free PMC Article
    5. In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor. Baker FC, et al. Development, 2021 Nov 15. PMID 35020877, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    helicase with zinc finger
    Names
    CG9425-PB
    CG9425-PC
    CG9425-PD
    Helz-PB
    Helz-PC
    Helz-PD
    NP_001261848.1
    NP_648725.2
    NP_996084.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14789935..14801089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206362.2 → NP_996084.1  helicase with zinc finger, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996084.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUL0, Q9VUH9
      Conserved Domains (4) summary
      cd00009
      Location:810 → 886
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      TIGR00376
      Location:657 → 1236
      TIGR00376; DNA helicase, putative
      pfam00642
      Location:329 → 353
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13087
      Location:1003 → 1213
      AAA_12; AAA domain

    2. NM_001274919.2 → NP_001261848.1  helicase with zinc finger, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUL0, Q9VUH9
      Conserved Domains (4) summary
      cd00009
      Location:810 → 886
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      TIGR00376
      Location:657 → 1236
      TIGR00376; DNA helicase, putative
      pfam00642
      Location:329 → 353
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13087
      Location:1003 → 1213
      AAA_12; AAA domain

    3. NM_140468.3 → NP_648725.2  helicase with zinc finger, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648725.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUL0, Q9VUH9
      Conserved Domains (4) summary
      cd00009
      Location:810 → 886
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      TIGR00376
      Location:657 → 1236
      TIGR00376; DNA helicase, putative
      pfam00642
      Location:329 → 353
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13087
      Location:1003 → 1213
      AAA_12; AAA domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR22 Q8MR22
    Q9VUH9 Q9VUH9

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