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    CG8142 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32763, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8142provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030871
    Locus tag
    Dmel_CG8142
    See related
    AllianceGenome:FB:FBgn0030871
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8142; DmRFC2; RfC; RFC2; Rfc37; rfc4
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and DNA binding activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in DNA repair and DNA-templated DNA replication. Part of Elg1 RFC-like complex. Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic central brain neurons; ganglia; and mesoderm. Orthologous to human RFC4 (replication factor C subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8142 in Genome Data Viewer
    Location:
    16E1-16E1; 1-59 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17843343..17844704, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17737376..17738737, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Suppressor of Cytokine Signaling at 16D Neighboring gene long non-coding RNA:CR44691 Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 9 Neighboring gene Uncoupling protein 4A Neighboring gene uncharacterized protein Neighboring gene Spt7 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants. Krause SA, et al. Mol Cell Biol, 2001 Aug. PMID 11438670, Free PMC Article
    2. Transcriptional regulation of the Drosophila rfc1 gene by the DRE-DREF pathway. Tsuchiya A, et al. FEBS J, 2007 Apr. PMID 17381512
    3. The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition. Huang F, et al. Genes Dev, 2016 May 15. PMID 27198229, Free PMC Article
    4. Whole transcriptome screening for novel genes involved in meiosis and fertility in Drosophila melanogaster. Sun S, et al. Sci Rep, 2024 Feb 13. PMID 38351116, Free PMC Article
    5. Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila. Kind J, et al. Cell, 2008 May 30. PMID 18510926

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Elg1 RFC-like complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8142-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17843343..17844704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133017.4 → NP_573245.1  uncharacterized protein Dmel_CG8142 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573245.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T033, Q9VX15
      Related
      FBpp0074246
      Conserved Domains (4) summary
      cd00009
      Location:45 → 187
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      PRK00440
      Location:31 → 344
      rfc; replication factor C small subunit; Reviewed
      pfam08542
      Location:293 → 344
      Rep_fac_C; Replication factor C C-terminal domain
      pfam16193
      Location:211 → 256
      AAA_assoc_2; AAA C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX15 Q9VX15

    Gene LinkOut

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