U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG11596 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31158, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG11596provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023522
    Locus tag
    Dmel_CG11596
    See related
    AllianceGenome:FB:FBgn0023522
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11596; EG:39E1.1
    Summary
    Enables amino acid sensor activity. Involved in cellular response to amino acid starvation; cellular response to methionine; and negative regulation of TORC1 signaling. Predicted to be active in cytosol and nucleus. Is expressed in organism. Orthologous to human CARNMT1 (carnosine N-methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG11596 in Genome Data Viewer
    Location:
    2B16-2B16; 1-0.2 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1927683..1930517)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1821716..1824550)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Myb-interacting protein 130 Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon Neighboring gene Oculocerebrorenal syndrome of Lowe Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway. Liu GY, et al. Nat Commun, 2024 Mar 21. PMID 38514639, Free PMC Article
    2. The Drosophila MSL complex activates the transcription of target genes. Straub T, et al. Genes Dev, 2005 Oct 1. PMID 16204179, Free PMC Article
    3. Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila. Monzo K, et al. Dev Biol, 2010 Apr 15. PMID 20122915, Free PMC Article
    4. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
    5. Adaptation to Chronic Nutritional Stress Leads to Reduced Dependence on Microbiota in Drosophila melanogaster. Erkosar B, et al. mBio, 2017 Oct 24. PMID 29066546, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amino acid sensor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carnosine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnosine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carnosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carnosine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to methionine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG11596-PA
    CG11596-PB
    CG11596-PC
    CG11596-PD
    CG11596-PE
    NP_001259154.1
    NP_001259155.1
    NP_569963.1
    NP_726779.1
    NP_726780.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1927683..1930517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130607.3 → NP_569963.1  uncharacterized protein Dmel_CG11596, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46078, Q7KW04, Q9I7X6, Q9W540
      Related
      FBpp0070306
      Conserved Domains (1) summary
      pfam07942
      Location:114 → 379
      N2227; N2227-like protein

    2. NM_166916.2 → NP_726779.1  uncharacterized protein Dmel_CG11596, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKI7
      Related
      FBpp0070305
      Conserved Domains (1) summary
      pfam07942
      Location:114 → 396
      N2227; N2227-like protein

    3. NM_001272226.1 → NP_001259155.1  uncharacterized protein Dmel_CG11596, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGG7
      Conserved Domains (1) summary
      pfam07942
      Location:59 → 341
      N2227; N2227-like protein

    4. NM_166917.2 → NP_726780.1  uncharacterized protein Dmel_CG11596, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGG7
      Related
      FBpp0070307
      Conserved Domains (1) summary
      pfam07942
      Location:59 → 341
      N2227; N2227-like protein

    5. NM_001272225.1 → NP_001259154.1  uncharacterized protein Dmel_CG11596, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGG7
      Conserved Domains (1) summary
      pfam07942
      Location:59 → 341
      N2227; N2227-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGG7 M9PGG7
    Q9I7X6.1 Q9I7X6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous