Rplp1 ribosomal protein lateral stalk subunit P1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rplp1provided by MGI
Official Full Name: ribosomal protein lateral stalk subunit P1provided by MGI
Primary source: MGI:MGI:1927099
See related: Ensembl:ENSMUSG00000007892 AllianceGenome:MGI:1927099
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arpp1; 2410042H16Rik; C430017H15Rik
Summary: Predicted to enable protein kinase activator activity and ribonucleoprotein complex binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within regulation of translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Orthologous to human RPLP1 (ribosomal protein lateral stalk subunit P1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 3167.4), stomach adult (RPKM 2818.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 33.5 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (61820565..61821792, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (61913283..61914510, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in metabolic dysfunction-associated steatohepatitis and reversed by alternate day fasting.
Title: Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in metabolic dysfunction-associated steatohepatitis and reversed by alternate day fasting.
60S acidic ribosomal protein P1 (RPLP1) is elevated in human endometriotic tissue and in a murine model of endometriosis and is essential for endometriotic epithelial cell survival in vitro.
Title: 60S acidic ribosomal protein P1 (RPLP1) is elevated in human endometriotic tissue and in a murine model of endometriosis and is essential for endometriotic epithelial cell survival in vitro.
Results show that Rplp1 was essential for embryonic and brain development; its deletion provokes a stress response associated with misfolded proteins inducing a different translation pattern.
Title: RPLP1, a crucial ribosomal protein for embryonic development of the nervous system.
overexpression of a single ribosomal protein, Rplp1, is a cause and not a consequence of cell proliferation
Title: Rplp1 bypasses replicative senescence and contributes to transformation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RPLP1 (e-PCR)
- UniSTS:503125

RH136544 (e-PCR)
- UniSTS:210526

D15S1202 (e-PCR)
- UniSTS:73374

RPLP1 (e-PCR)
- UniSTS:266204

MARC_5765-5766:997299257:1 (e-PCR)
- UniSTS:269565

PMC156124P1 (e-PCR)
- UniSTS:271359

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoprotein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IPI Inferred from Physical Interaction more info	PubMed
part_of cytosolic large ribosomal subunit	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in ribosome	NAS Non-traceable Author Statement more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: large ribosomal subunit protein P1

Names: 60S acidic ribosomal protein P1; acidic ribosomal phosphoprotein P1; ribosomal protein, large, P1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018853.3 → NP_061341.1 large ribosomal subunit protein P1

See identical proteins and their annotated locations for NP_061341.1

Status: PROVISIONAL

Source sequence(s)

AC151969

Consensus CDS

CCDS23260.1

UniProtKB/Swiss-Prot

P47955

UniProtKB/TrEMBL

Q58E35

Related

ENSMUSP00000008036.8, ENSMUST00000008036.9

Conserved Domains (1) summary

cd05831
Location:6 → 63

Ribosomal_P1; Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins ...