Nr2f1 nuclear receptor subfamily 2, group F, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nr2f1provided by MGI
Official Full Name: nuclear receptor subfamily 2, group F, member 1provided by MGI
Primary source: MGI:MGI:1352451
See related: Ensembl:ENSMUSG00000069171 AllianceGenome:MGI:1352451
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EAR3; EAR-3; SVP44; Erbal3; COUPTFA; COUP-TF1; COUP-TFI; Tcfcoup1
Summary: Enables sequence-specific DNA binding activity. Acts upstream of or within nervous system development and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; gut; and sensory organ. Used to study Bosch-Boonstra-Schaaf optic atrophy syndrome. Human ortholog(s) of this gene implicated in Bosch-Boonstra-Schaaf optic atrophy syndrome. Orthologous to human NR2F1 (nuclear receptor subfamily 2 group F member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 49.7), CNS E14 (RPKM 43.7) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 41.38 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (78337090..78346954, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (78188971..78198873, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NR2F1 shapes mitochondria in the mouse brain, providing new insights into Bosch-Boonstra-Schaaf optic atrophy syndrome.
Title: NR2F1 shapes mitochondria in the mouse brain, providing new insights into Bosch-Boonstra-Schaaf optic atrophy syndrome.
Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver.
Title: Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver.
COUP-TFI/Nr2f1 Orchestrates Intrinsic Neuronal Activity during Development of the Somatosensory Cortex.
Title: COUP-TFI/Nr2f1 Orchestrates Intrinsic Neuronal Activity during Development of the Somatosensory Cortex.
Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.
Title: Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.
NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients.
Title: NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients.
Mouse Nr2f1 haploinsufficiency results in model of Bosch-Boonstra-Schaaf optic atrophy.
Title: Mouse Nr2f1 haploinsufficiency unveils new pathological mechanisms of a human optic atrophy syndrome.
Loss of Nr2f1 in mouse cortex leads to increased locomotor activity but less anxiety.
Title: Hyperactive and anxiolytic-like behaviors result from loss of COUP-TFI/Nr2f1 in the mouse cortex.
COUP-TFI as a central regulator of the neuron-astroglia cell fate decision and a key modulator during neuroinflammation in the adult hippocampus.
Title: Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo.
These data support a translational control of COUP-TFI gradient expression by FGF8 via miR-21 and contribute to our understanding of how regionalized expression is established during neocortical area mapping.
Title: The microRNA miR-21 Is a Mediator of FGF8 Action on Cortical COUP-TFI Translation.
These results indicate that COUP-TF1 plays an important role in modulating the timing and magnitude of T3-stimulated gene expression required for normal corticogenesis.
Title: COUP-TF1 Modulates Thyroid Hormone Action in an Embryonic Stem-Cell Model of Cortical Pyramidal Neuronal Differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nr2f1 (e-PCR), detects polymorphism
- UniSTS:530692

NoName (e-PCR)
- UniSTS:489758

PMC316414P1 (e-PCR)
- UniSTS:272986

Nr2f1 (e-PCR), detects polymorphism
- UniSTS:527003

Nr2f1 (e-PCR), detects polymorphism
- UniSTS:186524

Nr2f1 (e-PCR), detects polymorphism
- UniSTS:547278

Nr2f1 (e-PCR), detects polymorphism
- UniSTS:498395

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables retinoic acid-responsive element binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cerebral cortex regionalization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within interneuron migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: COUP transcription factor 1

Names: COUP transcription factor I; V-erbA-related protein 3; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347538.2 → NP_001334467.1 COUP transcription factor 1 isoform b

Status: VALIDATED

Source sequence(s)

CT025642

Consensus CDS

CCDS84040.1

UniProtKB/TrEMBL

F7CII1

Related

ENSMUSP00000122618.3, ENSMUST00000125176.3

Conserved Domains (1) summary

cd06948
Location:34 → 269

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
NM_001347539.2 → NP_001334468.1 COUP transcription factor 1 isoform c

Status: VALIDATED

Source sequence(s)

CT025642

Consensus CDS

CCDS84039.1

UniProtKB/TrEMBL

B8JJI9, G3UXI5

Related

ENSMUSP00000118161.2, ENSMUST00000150498.8

Conserved Domains (1) summary

cd06948
Location:24 → 259

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
NM_001403773.1 → NP_001390702.1 COUP transcription factor 1 isoform b

Status: VALIDATED

Source sequence(s)

CT025642

UniProtKB/TrEMBL

F7CII1
NM_001403775.1 → NP_001390704.1 COUP transcription factor 1 isoform b

Status: VALIDATED

Source sequence(s)

CT025642

UniProtKB/TrEMBL

F7CII1
NM_001403777.1 → NP_001390706.1 COUP transcription factor 1 isoform b

Status: VALIDATED

Source sequence(s)

CT025642

UniProtKB/TrEMBL

F7CII1
NM_010151.4 → NP_034281.2 COUP transcription factor 1 isoform a

See identical proteins and their annotated locations for NP_034281.2

Status: VALIDATED

Source sequence(s)

CT025642

Consensus CDS

CCDS26658.1

UniProtKB/Swiss-Prot

Q60632, Q61438

UniProtKB/TrEMBL

Q32NY6

Related

ENSMUSP00000089036.7, ENSMUST00000091458.13

Conserved Domains (2) summary

cd06948
Location:181 → 416

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

cd06958
Location:83 → 155

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

78337090..78346954 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517085.3 → XP_006517148.1 COUP transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

Q60632, Q61438

Conserved Domains (2) summary

cd06948
Location:180 → 415

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

cd06958
Location:83 → 155

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers