Dtd1 D-tyrosyl-tRNA deacylase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dtd1provided by MGI
Official Full Name: D-tyrosyl-tRNA deacylase 1provided by MGI
Primary source: MGI:MGI:1913294
See related: Ensembl:ENSMUSG00000027430 AllianceGenome:MGI:1913294
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DTD; DUE-B; Hars2; 0610006H08Rik
Summary: Predicted to enable D-tyrosyl-tRNA(Tyr) deacylase activity and DNA binding activity. Predicted to be involved in DNA duplex unwinding and tRNA metabolic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human DTD1 (D-aminoacyl-tRNA deacylase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 18.3), cerebellum adult (RPKM 17.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G1; 2 71.02 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (144441873..144610667)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (144599953..144768747)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225289

D2Mit403 (e-PCR), detects polymorphism
- UniSTS:129307

D2Mit403.1 (e-PCR), detects polymorphism
- UniSTS:129308

NoName (e-PCR)
- UniSTS:225055

NoName (e-PCR)
- UniSTS:234544

NoName (e-PCR)
- UniSTS:224829

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-tyrosyl-tRNA(Tyr) deacylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-tyrosyl-tRNA(Tyr) deacylase activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in aminoacyl-tRNA metabolism involved in translational fidelity	IEA Inferred from Electronic Annotation more info
involved_in tRNA metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: D-aminoacyl-tRNA deacylase 1

Names: D-tyrosyl-tRNA deacylase 1 homolog; D-tyrosyl-tRNA(Tyr) deacylase 1; DNA-unwinding element-binding protein B; gly-tRNA(Ala) deacylase

NP_079590.1

EC 3.1.1.96

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025314.3 → NP_079590.1 D-aminoacyl-tRNA deacylase 1

See identical proteins and their annotated locations for NP_079590.1

Status: VALIDATED

Source sequence(s)

AK003594, AK011917, BE633558, BY294360

Consensus CDS

CCDS16824.1

UniProtKB/Swiss-Prot

A2ANA2, Q3TY44, Q9CRE8, Q9CYL0, Q9D013, Q9D1G4, Q9DD18

Related

ENSMUSP00000028917.7, ENSMUST00000028917.7

Conserved Domains (1) summary

cd00563
Location:1 → 147

Dtyr_deacylase; D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not ...