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    malQ 4-alpha-glucanotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947923, updated on 3-Dec-2024

    Summary

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    Official Symbol
    malQ
    Official Full Name
    4-alpha-glucanotransferase
    Primary source
    ECOCYC:EG10561
    Locus tag
    b3416
    See related
    ASAP:ABE-0011151
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3403; malA
    Summary
    MalT regulon. [More information is available at EcoGene: EG10561]. Amylomaltase was first described as a maltose-inducible enzyme that catalyzes a reversible transglycosidase reaction . [More information is available at EcoCyc: EG10561].
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    Genomic context

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    Sequence:
    NC_000913.3 (3547986..3550070, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster carrier protein NfuA Neighboring gene high-affinity gluconate transporter Neighboring gene maltodextrin phosphorylase Neighboring gene DNA-binding transcriptional activator MalT

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the Transglycosylation Reaction of 4-α-Glucanotransferase (MalQ) and Its Role in Glycogen Breakdown in Escherichia coli. Nguyen DHD, et al. J Microbiol Biotechnol, 2019 Mar 28. PMID 30691252
    2. The action pattern of amylomaltase from Escherichia coli. Palmer TN, et al. Eur J Biochem, 1976 Oct 1. PMID 791642
    3. Direct utilization of maltose by Escherichia coli. DOUDOROFF M, et al. J Biol Chem, 1949 Jun. PMID 18150023
    4. Genetic analysis of the maltose A region in Escherichia coli. Hatfield D, et al. J Bacteriol, 1969 May. PMID 4891257, Free PMC Article
    5. Nonsense mutations in the maltose A region of the genetic map of Escherichia coli. Hatfield D, et al. J Bacteriol, 1969 Dec. PMID 4902812, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The action of MalQ on maltose or maltodextrin can lead to the formation of glycogen and that MalP controls (inhibits) this pathway.
      Title: Role of maltose enzymes in glycogen synthesis by Escherichia coli.
    2. The fact that glk malQ+ mutants showed elevated mal gene expression finds its explanation in the reduced ability to remove glucose from MalQ-catalyzed maltodextrin formation and is caused by a metabolically induced MalQ- phenotype.
      Title: Glucose- and glucokinase-controlled mal gene expression in Escherichia coli.
    3. A comparison of ATPHS2 and DPE2 from A. thaliana with MalP and MalQ from E. coli is presented.
      Title: The role of cytosolic alpha-glucan phosphorylase in maltose metabolism and the comparison of amylomaltase in Arabidopsis and Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4-alpha-glucanotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-alpha-glucanotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-alpha-glucanotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycogen biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maltose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within maltose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    4-alpha-glucanotransferase
    NP_417875.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3547986..3550070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417875.1 4-alpha-glucanotransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417875.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GHL0, A0A376WSK2, A0A6M9WXH2
      Conserved Domains (1) summary
      PRK11052
      Location:1 → 684
      malQ; 4-alpha-glucanotransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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