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    melA alpha-galactosidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948636, updated on 3-Dec-2024

    Summary

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    Official Symbol
    melA
    Official Full Name
    alpha-galactosidase
    Primary source
    ECOCYC:EG10577
    Locus tag
    b4119
    See related
    ASAP:ABE-0013493
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4112; mel-7
    Summary
    Alpha-galactosidase was previously thought to be a tetramer, but is now believed to be a dimer. [More information is available at EcoCyc: EG10577].
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    Genomic context

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    Sequence:
    NC_000913.3 (4341911..4343266)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene arginine decarboxylase, degradative Neighboring gene DNA-binding transcriptional dual regulator MelR Neighboring gene melibiose:H(+)/Na(+)/Li(+) symporter Neighboring gene DUF2238 domain-containing inner membrane protein YjdF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Melibiose permease and alpha-galactosidase of Escherichia coli: identification by selective labeling using a T7 RNA polymerase/promoter expression system. Pourcher T, et al. Biochemistry, 1990 Jan 23. PMID 2159786
    2. Synthesis of 5-amino-5-deoxy-D-galactopyranose and 1,5-dideoxy-1,5-imino-D-galactitol, and their inhibition of alpha- and beta-D-galactosidases. Legler G, et al. Carbohydr Res, 1986 Nov 1. PMID 3024831
    3. Nucleotide sequence of the melA gene, coding for alpha-galactosidase in Escherichia coli K-12. Liljeström PL, et al. Nucleic Acids Res, 1987 Mar 11. PMID 3031590, Free PMC Article
    4. Analysis of melibiose mutants deficient in alpha-galactosidase and thiomethylgalactoside permease II in Escherichia coli K-12. Schmitt R. J Bacteriol, 1968 Aug. PMID 4877127, Free PMC Article
    5. Alpha-galactosidase activity in cell-free extracts of Escherichia coli. Schmitt R, et al. Biochem Biophys Res Commun, 1966 Mar 8. PMID 5329906

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: The Aes protein and the monomeric alpha-galactosidase from Escherichia coli form a non-covalent complex. Implications for the regulation of carbohydrate metabolism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NAD+ binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-galactosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-galactosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-galactosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within melibiose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-galactosidase
    NP_418543.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4341911..4343266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418543.1 alpha-galactosidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418543.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GHT3, A0A2H4TRS8, A0A8S7CP62
      Conserved Domains (1) summary
      PRK15076
      Location:4 → 449
      PRK15076; alpha-galactosidase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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