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    mdtL efflux pump MdtL [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948219, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mdtL
    Official Full Name
    efflux pump MdtL
    Primary source
    ECOCYC:EG11720
    Locus tag
    b3710
    See related
    ASAP:ABE-0012139
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3703; yidY
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG11720]. The YidY protein is, based on sequence similarity and hydropathy analysis, a member of the major facilitator superfamily (MFS) . [More information is available at EcoCyc: EG11720].
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    Genomic context

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    Sequence:
    NC_000913.3 (3891615..3892790)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tryptophanase Neighboring gene tryptophan:H(+) symporter TnaB Neighboring gene DNA-binding transcriptional dual regulator YidZ Neighboring gene putative phosphopantetheinyl transferase Neighboring gene quinone reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microbial genome analyses: comparative transport capabilities in eighteen prokaryotes. Paulsen IT, et al. J Mol Biol, 2000 Aug 4. PMID 10926494
    2. Proton-dependent multidrug efflux systems. Paulsen IT, et al. Microbiol Rev, 1996 Dec. PMID 8987357, Free PMC Article
    3. Analysis of a complete library of putative drug transporter genes in Escherichia coli. Nishino K, et al. J Bacteriol, 2001 Oct. PMID 11566977, Free PMC Article
    4. Microbial drug efflux proteins of the major facilitator superfamily. Saidijam M, et al. Curr Drug Targets, 2006 Jul. PMID 16842212
    5. The major facilitator superfamily. Saier MH Jr, et al. J Mol Microbiol Biotechnol, 1999 Nov. PMID 10943556

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    efflux pump MdtL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3891615..3892790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418166.1 efflux pump MdtL [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418166.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6PMY2
      Conserved Domains (1) summary
      PRK10473
      Location:1 → 391
      PRK10473; MdtL family multidrug efflux MFS transporter
    Nucleotide Protein
    Heading Accession and Version

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