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    narK nitrate:nitrite antiporter NarK [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945783, updated on 3-Dec-2024

    Summary

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    Official Symbol
    narK
    Official Full Name
    nitrate:nitrite antiporter NarK
    Primary source
    ECOCYC:EG10642
    Locus tag
    b1223
    See related
    ASAP:ABE-0004111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1217
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG10642]. NarU and NarK are the two nitrate transporters in Escherichia coli. [More information is available at EcoCyc: EG10642].
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    Genomic context

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    Sequence:
    NC_000913.3 (1277957..1279348)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative invasin YchO Neighboring gene DNA-binding transcriptional dual regulator NarL Neighboring gene sensor histidine kinase NarX Neighboring gene ncRNA Neighboring gene nitrate reductase A subunit alpha Neighboring gene nitrate reductase A subunit beta Neighboring gene nitrate reductase 1 molybdenum cofactor assembly chaperone Neighboring gene nitrate reductase A subunit gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. How do antiporters exchange substrates across the cell membrane? An atomic-level description of the complete exchange cycle in NarK. Feng J, et al. Structure, 2021 Aug 5. PMID 33836147
    2. Influence of nar (nitrate reductase) genes on nitrate inhibition of formate-hydrogen lyase and fumarate reductase gene expression in Escherichia coli K-12. Stewart V, et al. J Bacteriol, 1988 Oct. PMID 3049531, Free PMC Article
    3. Regulation of narK gene expression in Escherichia coli in response to anaerobiosis, nitrate, iron, and molybdenum. Kolesnikow T, et al. J Bacteriol, 1992 Nov. PMID 1429433, Free PMC Article
    4. Identification of functional cis-acting sequences involved in regulation of narK gene expression in Escherichia coli. Bonnefoy V, et al. Mol Microbiol, 1992 Dec. PMID 1474901
    5. Isolation of an oxygen-sensitive FNR protein of Escherichia coli: interaction at activator and repressor sites of FNR-controlled genes. Melville SB, et al. Proc Natl Acad Sci U S A, 1996 Feb 6. PMID 8577745, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables nitrate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitrite transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables solute:inorganic anion antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nitrate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitrate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitrate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitrate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitrite transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitrite transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nitrate:nitrite antiporter NarK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1277957..1279348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415741.1 nitrate:nitrite antiporter NarK [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415741.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A895P481
      Conserved Domains (1) summary
      cl28910
      Location:8 → 463
      MFS; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version

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