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    dcuA C4-dicarboxylate transporter DcuA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948659, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dcuA
    Official Full Name
    C4-dicarboxylate transporter DcuA
    Primary source
    ECOCYC:EG11225
    Locus tag
    b4138
    See related
    ASAP:ABE-0013546
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4132; genA
    Summary
    IT (Ion Transporter) superfamily (Prakash, 2003). [More information is available at EcoGene: EG11225]. The DcuA transporter is one of three transporters known to be responsible for the uptake of C4-dicarboxylates such as fumarate under anaerobic conditions. [More information is available at EcoCyc: EG11225].
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    Genomic context

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    Sequence:
    NC_000913.3 (4365472..4366773, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative DNA-binding transcriptional regulator YjdC Neighboring gene thiol-disulfide exchange protein DsbD Neighboring gene copper binding protein CutA Neighboring gene ncRNA Neighboring gene aspartate ammonia-lyase Neighboring gene protein FxsA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and nucleotide sequence of the aspartase gene of Escherichia coli W. Takagi JS, et al. Nucleic Acids Res, 1985 Mar 25. PMID 2987841, Free PMC Article
    2. Influence of C(4) -Dcu transporters on hydrogenase and formate dehydrogenase activities in stationary phase-grown fermenting Escherichia coli. Karapetyan L, et al. IUBMB Life, 2020 Aug. PMID 32277802
    3. Anaerobic fumarate transport in Escherichia coli by an fnr-dependent dicarboxylate uptake system which is different from the aerobic dicarboxylate uptake system. Engel P, et al. J Bacteriol, 1992 Sep. PMID 1512189, Free PMC Article
    4. Transport of C4-dicarboxylates by anaerobically grown Escherichia coli. Energetics and mechanism of exchange, uptake and efflux. Engel P, et al. Eur J Biochem, 1994 Jun 1. PMID 8020497
    5. C4-dicarboxylate metabolons: interaction of C4-dicarboxylate transporters of Escherichia coli with cytosolic enzymes. Schubert C, et al. FEMS Microbiol Lett, 2022 Sep 22. PMID 36044995

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Influence of C4 -Dcu transporters on hydrogenase and formate dehydrogenase activities in stationary phase-grown fermenting Escherichia coli.
      Title: Influence of C(4) -Dcu transporters on hydrogenase and formate dehydrogenase activities in stationary phase-grown fermenting Escherichia coli.
    2. In this work, it is shown that DcuA is required for aerobic growth with L-aspartate as a nitrogen source.
      Title: DcuA of aerobically grown Escherichia coli serves as a nitrogen shuttle (L-aspartate/fumarate) for nitrogen uptake.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables C4-dicarboxylate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables C4-dicarboxylate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables succinate:fumarate antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within C4-dicarboxylate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in C4-dicarboxylate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-aspartate import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within anaerobic respiration EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in fumarate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C4-dicarboxylate transporter DcuA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4365472..4366773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418561.1 C4-dicarboxylate transporter DcuA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418561.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A765T1T9
      Conserved Domains (1) summary
      PRK09412
      Location:1 → 433
      PRK09412; anaerobic C4-dicarboxylate transporter; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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