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    aer aerotaxis receptor [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945301, updated on 3-Dec-2024

    Summary

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    Official Symbol
    aer
    Official Full Name
    aerotaxis receptor
    Primary source
    ECOCYC:G7595
    Locus tag
    b3072
    See related
    ASAP:ABE-0010087
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    air; ECK3062; yqjJ
    Summary
    Energy taxis includes aerotaxis, redox taxis and glycerol taxis. aer is up-regulated by FlhCD and CRP. aer mutants are down for genes involved in anaerobic respiration and the Entner-Doudoroff pathway. [More information is available at EcoGene: EG12955]. The flavoprotein Aer is one of two sensory proteins which mediate the aerotactic response in Escherichia coli. [More information is available at EcoCyc: G7595].
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    Genomic context

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    Sequence:
    NC_000913.3 (3217556..3219076, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene NADPH-dependent ferric-chelate reductase Neighboring gene DNA-binding transcriptional repressor NfeR Neighboring gene putrescine aminotransferase Neighboring gene putative tRNA-binding protein YgjH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In search of higher energy: metabolism-dependent behaviour in bacteria. Taylor BL, et al. Mol Microbiol, 1998 May. PMID 9643537
    2. Aerotactic responses in bacteria to photoreleased oxygen. Yu HS, et al. FEMS Microbiol Lett, 2002 Dec 17. PMID 12480110
    3. An alternative strategy for adaptation in bacterial behavior. Taylor BL. J Bacteriol, 2004 Jun. PMID 15175278, Free PMC Article
    4. Interactions between the PAS and HAMP domains of the Escherichia coli aerotaxis receptor Aer. Watts KJ, et al. J Bacteriol, 2004 Nov. PMID 15489456, Free PMC Article
    5. The Aer protein of Escherichia coli forms a homodimer independent of the signaling domain and flavin adenine dinucleotide binding. Ma Q, et al. J Bacteriol, 2004 Nov. PMID 15489458, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blue light is a universal signal for Escherichia coli chemoreceptors.
      Title: Blue Light Is a Universal Signal for Escherichia coli Chemoreceptors.
    2. Oxidized Aer activates CheA, whereas ASQ Aer reversibly inhibits CheA.
      Title: Bacterial Energy Sensor Aer Modulates the Activity of the Chemotaxis Kinase CheA Based on the Redox State of the Flavin Cofactor.
    3. These studies demonstrated trigonal interactions among the F1 linkers from three Aer monomers, presumably within trimer-of-dimer units, as well as binary interactions between subunits.
      Title: Role of the F1 region in the Escherichia coli aerotaxis receptor Aer.
    4. Gain-of-function mutations are associated with the signalling pathway in the PAS domain of Aer.
      Title: Gain-of-function mutations cluster in distinct regions associated with the signalling pathway in the PAS domain of the aerotaxis receptor, Aer.
    5. The aer mutant exhibited a decreased ability to colonize the intestine when compared to wild-type cells.
      Title: An Escherichia coli aer mutant exhibits a reduced ability to colonize the streptomycin-treated mouse large intestine.
    6. Data confirmed that the Aer HAMP domain is composed of two alpha-helices separated by a structured loop and significance of the HAMP and proximal signaling domain structure for signal transduction is discussed.
      Title: Structure-function relationships in the HAMP and proximal signaling domains of the aerotaxis receptor Aer.
    7. the overall membrane organization of Aer included a maximum of three Aer dimers, did not swap neighbors over time, and appeared to be constrained by interactions in the cytosolic signaling domain.
      Title: Organization of the aerotaxis receptor aer in the membrane of Escherichia coli.
    8. Either the PAS or signalling domains could be deleted from the non-signalling subunit of the Aer heterodimer, but removing 16 residues from the C-terminus of the signalling subunit abolished aerotaxis.
      Title: Minimal requirements for oxygen sensing by the aerotaxis receptor Aer.
    9. EilA activates the genetically linked high molecular weight bacterial surface protein Air
      Title: EilA, a HilA-like regulator in enteroaggregative Escherichia coli.
    10. strong Aer responses to oxygen are associated with redox changes in NADH dehydrogenase I
      Title: Differentiation between electron transport sensing and proton motive force sensing by the Aer and Tsr receptors for aerotaxis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive aerotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aerotaxis receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3217556..3219076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417543.1 aerotaxis receptor [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417543.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8R5H2
      Conserved Domains (2) summary
      smart00283
      Location:259 → 506
      MA; Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)
      pfam08447
      Location:30 → 115
      PAS_3; PAS fold
    Nucleotide Protein
    Heading Accession and Version

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