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    hemD uroporphyrinogen-III synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948587, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hemD
    Official Full Name
    uroporphyrinogen-III synthase
    Primary source
    ECOCYC:EG10430
    Locus tag
    b3804
    See related
    ASAP:ABE-0012425
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3798
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    Genomic context

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    Sequence:
    NC_000913.3 (3989088..3989828, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein HemY Neighboring gene PF04375 family protein HemX Neighboring gene hydroxymethylbilane synthase Neighboring gene adenylate cyclase Neighboring gene frataxin CyaY Neighboring gene protein YzcX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence for the hemD gene of Escherichia coli encoding uroporphyrinogen III synthase and initial evidence for a hem operon. Jordan PM, et al. Biochem J, 1988 Jan 15. PMID 3277628, Free PMC Article
    2. Nucleotide sequence of hemD, the second gene in the hem operon of Escherichia coli K-12. Jordan PM, et al. Nucleic Acids Res, 1987 Dec 23. PMID 3320969, Free PMC Article
    3. Molecular cloning and sequencing of the hemD gene of Escherichia coli K-12 and preliminary data on the Uro operon. Sasarman A, et al. J Bacteriol, 1987 Sep. PMID 3040684, Free PMC Article
    4. Purification and properties of uroporphyrinogen III synthase (co-synthase) from an overproducing recombinant strain of Escherichia coli K-12. Alwan AF, et al. Biochem J, 1989 Dec 1. PMID 2557837, Free PMC Article
    5. The sequence of hemC, hemD and two additional E. coli genes. Alefounder PR, et al. Nucleic Acids Res, 1988 Oct 25. PMID 3054815, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uroporphyrinogen-III synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uroporphyrinogen-III synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in uroporphyrinogen III biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uroporphyrinogen-III synthase
    NP_418248.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3989088..3989828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418248.1 uroporphyrinogen-III synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418248.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      W1F2Z4
      Conserved Domains (1) summary
      PRK05928
      Location:1 → 246
      hemD; uroporphyrinogen-III synthase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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