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    dosC diguanylate cyclase DosC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945835, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dosC
    Official Full Name
    diguanylate cyclase DosC
    Primary source
    ECOCYC:G6784
    Locus tag
    b1490
    See related
    ASAP:ABE-0004965
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dgcO; ECK1484; yddV
    Summary
    YddV/Dos may constitute a cyclic-diGMP synthesis/degradation module (Mendez-Ortiz, 2006). [More information is available at EcoGene: EG13793]. YddV is a diguanylate cyclase. [More information is available at EcoCyc: G6784].
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    Genomic context

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    Sequence:
    NC_000913.3 (1565758..1567140, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-alanyl-D-alanine dipeptidase Neighboring gene oxygen-sensing c-di-GMP phosphodiesterase DosP Neighboring gene protein YddY Neighboring gene divisome localized glycosyl hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The importance of conserved amino acids in heme-based globin-coupled diguanylate cyclases. Wan X, et al. PLoS One, 2017. PMID 28792538, Free PMC Article
    2. Structural analysis of an oxygen-regulated diguanylate cyclase. Tarnawski M, et al. Acta Crystallogr D Biol Crystallogr, 2015 Nov. PMID 26527135
    3. Probing the ligand recognition and discrimination environment of the globin-coupled oxygen sensor protein YddV by FTIR and time-resolved step-scan FTIR spectroscopy. Pavlou A, et al. Phys Chem Chem Phys, 2015 Jul 14. PMID 26063650
    4. The yddV-dos operon controls biofilm formation through the regulation of genes encoding curli fibers' subunits in aerobically growing Escherichia coli. Tagliabue L, et al. FEMS Immunol Med Microbiol, 2010 Aug. PMID 20553324
    5. Genome-wide transcriptional profile of Escherichia coli in response to high levels of the second messenger 3',5'-cyclic diguanylic acid. Méndez-Ortiz MM, et al. J Biol Chem, 2006 Mar 24. PMID 16418169

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DosC is a diguanylate cyclase that synthesizes c-di-GMP from GTP, whereas DosP is a phosphodiesterase that linearizes c-di-GMP to pGpG. [review]
      Title: Escherichia coli DosC and DosP: a role of c-di-GMP in compartmentalized sensing by degradosomes.
    2. Study reports the critical residues of globin-coupled diguanylate cyclases EcGReg (dosC) from Escherichia coli and BpeGReg from Bordetella pertussis; show that their diguanylate cyclase activity requires an intact globin domain. Results suggest distal residues of the globin domain affect diguanylate cyclase activity and that BpeGReg may interact with other c-di-GMP-metabolizing proteins to form mixed signaling teams
      Title: The importance of conserved amino acids in heme-based globin-coupled diguanylate cyclases.
    3. yddV positively controls pgaABCD expression and poly-N-acetylglucosamine production.
      Title: The diguanylate cyclase YddV controls production of the exopolysaccharide poly-N-acetylglucosamine (PNAG) through regulation of the PNAG biosynthetic pgaABCD operon.
    4. These results suggest that YddV and Dos, through their opposite activities, fine-tune curli production in response to oxygen availability.
      Title: The yddV-dos operon controls biofilm formation through the regulation of genes encoding curli fibers' subunits in aerobically growing Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbon monoxide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diguanylate cyclase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables diguanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diguanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diguanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion involved in single-species biofilm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of bacterial-type flagellum-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxygen levels IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    diguanylate cyclase DosC
    NP_416007.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1565758..1567140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416007.3 diguanylate cyclase DosC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416007.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A793GI31
      Conserved Domains (2) summary
      cd14757
      Location:7 → 153
      GS_EcDosC-like_GGDEF; Globin sensor domain of Escherichia coli Direct Oxygen Sensing Cyclase and related proteins; coupled to a C-terminal GGDEF domain
      pfam00990
      Location:297 → 452
      GGDEF; Diguanylate cyclase, GGDEF domain
    Nucleotide Protein
    Heading Accession and Version

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