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    mazG nucleoside triphosphate pyrophosphohydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947254, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mazG
    Official Full Name
    nucleoside triphosphate pyrophosphohydrolase
    Primary source
    ECOCYC:EG10572
    Locus tag
    b2781
    See related
    ASAP:ABE-0009117
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2775
    Summary
    MazG is a nucleoside pyrophosphohydrolase that limits the deleterious effect of the MazF toxin under nutritional stress conditions . [More information is available at EcoCyc: EG10572].
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    Genomic context

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    Sequence:
    NC_000913.3 (2909894..2910685, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene enolase Neighboring gene CTP synthetase Neighboring gene endoribonuclease toxin MazF Neighboring gene antitoxin of the MazF-MazE toxin-antitoxin system MazE Neighboring gene GDP/GTP pyrophosphokinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Energetics of MazG unfolding in correlation with its structural features. Drobnak I, et al. J Mol Biol, 2009 Sep 11. PMID 19523960
    2. Crystal structure of Escherichia coli MazG, the regulator of nutritional stress response. Lee S, et al. J Biol Chem, 2008 May 30. PMID 18353782, Free PMC Article
    3. House cleaning, a part of good housekeeping. Galperin MY, et al. Mol Microbiol, 2006 Jan. PMID 16359314
    4. Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions. Moroz OV, et al. J Mol Biol, 2005 Mar 25. PMID 15740738
    5. The regulation of the Escherichia coli mazEF promoter involves an unusual alternating palindrome. Marianovsky I, et al. J Biol Chem, 2001 Feb 23. PMID 11071896

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside triphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside triphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleoside triphosphate diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dATP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dGTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dTTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dUTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nucleoside triphosphate pyrophosphohydrolase
    NP_417261.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2909894..2910685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417261.1 nucleoside triphosphate pyrophosphohydrolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417261.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L5H8T0, A0A6N8R0Z7
      Conserved Domains (1) summary
      PRK09562
      Location:1 → 262
      mazG; nucleoside triphosphate pyrophosphohydrolase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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