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    ADAM22 ADAM metallopeptidase domain 22 [ Homo sapiens (human) ]

    Gene ID: 53616, updated on 10-Dec-2024

    Summary

    Official Symbol
    ADAM22provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 22provided by HGNC
    Primary source
    HGNC:HGNC:201
    See related
    Ensembl:ENSG00000008277 MIM:603709; AllianceGenome:HGNC:201
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDC2; DEE61; EIEE61; ADAM 22
    Summary
    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
    Expression
    Biased expression in brain (RPKM 9.0), adrenal (RPKM 2.5) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ADAM22 in Genome Data Viewer
    Location:
    7q21.12
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (87934251..88202889)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (89184170..89453378)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (87563566..87832204)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene origin of replication in promoter of DBF4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:87505271-87505780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26234 Neighboring gene uncharacterized LOC124901690 Neighboring gene DBF4-CDC7 kinase regulatory subunit Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:87556085-87556653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:87563985-87564562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:87564563-87565140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:87584727-87585228 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:87663457-87663957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26240 Neighboring gene uncharacterized LOC105375386 Neighboring gene MPRA-validated peak6626 silencer Neighboring gene uncharacterized LOC124901691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18356 Neighboring gene Sharpr-MPRA regulatory region 10982 Neighboring gene SRI antisense RNA 1 Neighboring gene sorcin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Developmental and epileptic encephalopathy, 61
    MedGen: C4693688 OMIM: 617933 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Genome-wide association study of serious blistering skin rash caused by drugs.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC149832

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables integrin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 22
    Names
    a disintegrin and metalloproteinase domain 22
    metalloproteinase-disintegrin ADAM22-3
    metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324417.2NP_001311346.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes isoform 6. The encoded isoform (6) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
      UniProtKB/TrEMBL
      Q08AL8
    2. NM_001324418.2NP_001311347.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes isoform 7. The encoded isoform (7) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
      Consensus CDS
      CCDS94137.1
      UniProtKB/TrEMBL
      A0A804HHS1, H7C3I4
      Related
      ENSP00000412085.2, ENST00000413139.2
    3. NM_001324419.2NP_001311348.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 8 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes isoform 8. The encoded isoform (8) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
      UniProtKB/TrEMBL
      A0A804HHS1
    4. NM_001324420.2NP_001311349.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 9 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) encodes isoform 9. The encoded isoform (9) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
      UniProtKB/TrEMBL
      A0A804HHS1
    5. NM_001324421.2NP_001311350.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 10 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) encodes isoform 10. The encoded isoform (10) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
      UniProtKB/TrEMBL
      Q08AL8
    6. NM_001391975.1NP_001378904.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:470545
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:547688
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:256455
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:102205
      Pep_M12B_propep; Reprolysin family propeptide
    7. NM_001391976.1NP_001378905.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:453528
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:71188
      Pep_M12B_propep; Reprolysin family propeptide
    8. NM_001391977.1NP_001378906.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:453528
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:71188
      Pep_M12B_propep; Reprolysin family propeptide
    9. NM_001391978.1NP_001378907.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:452527
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:529670
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:238437
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70187
      Pep_M12B_propep; Reprolysin family propeptide
    10. NM_001391979.1NP_001378908.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:452527
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:529670
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:238437
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70187
      Pep_M12B_propep; Reprolysin family propeptide
    11. NM_001391980.1NP_001378909.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 16 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:470545
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:547688
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:256455
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:102205
      Pep_M12B_propep; Reprolysin family propeptide
    12. NM_001391981.1NP_001378910.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 17 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:452527
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:529670
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:238437
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70187
      Pep_M12B_propep; Reprolysin family propeptide
    13. NM_001391982.1NP_001378911.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 18 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:445520
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:522663
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:241430
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:102205
      Pep_M12B_propep; Reprolysin family propeptide
    14. NM_004194.5NP_004185.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 4 precursor

      See identical proteins and their annotated locations for NP_004185.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as beta, uses an alternate splice site in the 3' coding region and lacks two downstream exons, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct C-terminus, compared to isoform 1. The encoded isoform (4) may undergo proteolytic processing.
      Source sequence(s)
      AB009671, AC005075, DR000609
      Consensus CDS
      CCDS43610.1
      UniProtKB/TrEMBL
      A0A804HHS1
      Related
      ENSP00000381260.4, ENST00000398201.8
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    15. NM_016351.6NP_057435.2  disintegrin and metalloproteinase domain-containing protein 22 isoform 3 precursor

      See identical proteins and their annotated locations for NP_057435.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as alpha, lacks an in-frame exon compared to variant 1. The encoded isoform (3) is shorter than isoform 1. The encoded isoform (3) may undergo proteolytic processing.
      Source sequence(s)
      AC005075, AC005164, AK291010, DR000609, R41888
      Consensus CDS
      CCDS43609.1
      UniProtKB/TrEMBL
      Q08AL8
      Related
      ENSP00000381262.4, ENST00000398204.8
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    16. NM_021721.5NP_068367.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 5 precursor

      See identical proteins and their annotated locations for NP_068367.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region and lacks one coding and two non-coding exons, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus, compared to isoform 1. The encoded isoform (5) may undergo proteolytic processing.
      Source sequence(s)
      AB009671, AC005075, AF155381, DR000609
      Consensus CDS
      CCDS94138.1
      UniProtKB/TrEMBL
      Q08AL8
      Related
      ENSP00000508320.1, ENST00000684002.1
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    17. NM_021722.6NP_068368.2  disintegrin and metalloproteinase domain-containing protein 22 isoform 2 precursor

      See identical proteins and their annotated locations for NP_068368.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as delta, has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. The encoded isoform (2) may undergo proteolytic processing.
      Source sequence(s)
      AC005075, AF155381, DR000609, R41888
      Consensus CDS
      CCDS43608.1
      UniProtKB/TrEMBL
      Q08AL8
      Related
      ENSP00000381267.3, ENST00000398209.7
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    18. NM_021723.5NP_068369.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_068369.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as epsilon, encodes isoform 1, which is proteolytically processed to generate the mature protein.
      Source sequence(s)
      AC005075, AF155382, DR000609, R41888
      Consensus CDS
      CCDS47637.1
      UniProtKB/Swiss-Prot
      O75075, O75076, Q9P0K1, Q9P0K2, Q9UIA1, Q9UKK2
      UniProtKB/TrEMBL
      Q08AL8
      Related
      ENSP00000265727.7, ENST00000265727.11
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      87934251..88202889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012330.3XP_016867819.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X9

      UniProtKB/TrEMBL
      A0A804HHS1
    2. XM_017012335.3XP_016867824.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X14

      UniProtKB/TrEMBL
      Q08AL8
    3. XM_011516318.3XP_011514620.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

      UniProtKB/TrEMBL
      A0A804HHS1
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    4. XM_011516322.3XP_011514624.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    5. XM_017012332.3XP_016867821.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

      UniProtKB/TrEMBL
      Q08AL8
    6. XM_017012333.3XP_016867822.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X13

      UniProtKB/TrEMBL
      A0A804HHS1
    7. XM_011516323.3XP_011514625.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    8. XM_011516319.4XP_011514621.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

      UniProtKB/TrEMBL
      A0A804HHS1
      Conserved Domains (5) summary
      smart00608
      Location:529670
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:238435
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:452526
      Disintegrin; Disintegrin
      pfam01421
      Location:238437
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:74186
      Pep_M12B_propep; Reprolysin family propeptide
    9. XM_006716028.5XP_006716091.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

      UniProtKB/TrEMBL
      B3KWN4
      Conserved Domains (5) summary
      smart00608
      Location:582723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505579
      Disintegrin; Disintegrin
      pfam01421
      Location:291490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127239
      Pep_M12B_propep; Reprolysin family propeptide
    10. XM_011516320.4XP_011514622.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

      UniProtKB/TrEMBL
      B3KWN4
      Conserved Domains (5) summary
      smart00608
      Location:582723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505579
      Disintegrin; Disintegrin
      pfam01421
      Location:291490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127239
      Pep_M12B_propep; Reprolysin family propeptide
    11. XM_011516321.4XP_011514623.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

      UniProtKB/TrEMBL
      B3KWN4
      Conserved Domains (5) summary
      smart00608
      Location:582723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505579
      Disintegrin; Disintegrin
      pfam01421
      Location:291490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127239
      Pep_M12B_propep; Reprolysin family propeptide
    12. XM_005250445.5XP_005250502.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

      UniProtKB/TrEMBL
      B3KWN4
      Conserved Domains (5) summary
      smart00608
      Location:582723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505579
      Disintegrin; Disintegrin
      pfam01421
      Location:291490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127239
      Pep_M12B_propep; Reprolysin family propeptide
    13. XM_006716029.5XP_006716092.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

      UniProtKB/TrEMBL
      B3KWN4
      Conserved Domains (5) summary
      smart00608
      Location:582723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505579
      Disintegrin; Disintegrin
      pfam01421
      Location:291490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127239
      Pep_M12B_propep; Reprolysin family propeptide
    14. XM_011516324.3XP_011514626.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

      UniProtKB/TrEMBL
      A0A804HHS1
      Conserved Domains (5) summary
      smart00608
      Location:456597
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:165362
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:379453
      Disintegrin; Disintegrin
      pfam01421
      Location:165364
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:8113
      Pep_M12B_propep; Reprolysin family propeptide

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      89184170..89453378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358425.1XP_054214400.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X9

      UniProtKB/TrEMBL
      A0A804HHS1
    2. XM_054358430.1XP_054214405.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X14

      UniProtKB/TrEMBL
      Q08AL8
    3. XM_054358418.1XP_054214393.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

      UniProtKB/TrEMBL
      A0A804HHS1
    4. XM_054358423.1XP_054214398.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

      UniProtKB/TrEMBL
      Q08AL8
    5. XM_054358427.1XP_054214402.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

      UniProtKB/TrEMBL
      Q08AL8
    6. XM_054358429.1XP_054214404.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X13

      UniProtKB/TrEMBL
      A0A804HHS1
    7. XM_054358426.1XP_054214401.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

      UniProtKB/TrEMBL
      Q08AL8
    8. XM_054358419.1XP_054214394.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

      UniProtKB/TrEMBL
      A0A804HHS1
    9. XM_054358417.1XP_054214392.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

      UniProtKB/TrEMBL
      B3KWN4
    10. XM_054358420.1XP_054214395.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

      UniProtKB/TrEMBL
      B3KWN4
    11. XM_054358421.1XP_054214396.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

      UniProtKB/TrEMBL
      B3KWN4
    12. XM_054358424.1XP_054214399.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

      UniProtKB/TrEMBL
      B3KWN4
    13. XM_054358422.1XP_054214397.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

      UniProtKB/TrEMBL
      B3KWN4
    14. XM_054358428.1XP_054214403.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

      UniProtKB/TrEMBL
      A0A804HHS1