Anxa13 annexin A13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anxa13provided by MGI
Official Full Name: annexin A13provided by MGI
Primary source: MGI:MGI:1917037
See related: Ensembl:ENSMUSG00000055114 AllianceGenome:MGI:1917037
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810034H17Rik
Summary: Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to be located in membrane and nucleoplasm. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in gut and metanephros. Orthologous to human ANXA13 (annexin A13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 22.5), small intestine adult (RPKM 5.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 24.66 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (58204860..58261123, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (58341464..58389274, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a mechanism for how the association of the ANX A13a isoform with the membrane is regulated
Title: An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding.
Mouse annexin A13 cDNA was used to map the gene to an orthologous linkage group in mouse chromosome 15 (between Sdc2 and Myc by backcross analysis).
Title: Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylglycerol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylglycerol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: annexin A13

Names: annexin XIII; annexin-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.