Sult1a1 sulfotransferase family 1A member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sult1a1provided by RGD
Official Full Name: sulfotransferase family 1A member 1provided by RGD
Primary source: RGD:3767
See related: EnsemblRapid:ENSRNOG00000019342 AllianceGenome:RGD:3767
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Stm; Stp1; ASTIV; Mx-ST; PST-1; St1a1; Sult1a3
Summary: Enables 3'-phosphoadenosine 5'-phosphosulfate binding activity; aryl sulfotransferase activity; and identical protein binding activity. Involved in several processes, including 4-nitrophenol metabolic process; estrogen metabolic process; and sulfation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 2372.3), Lung (RPKM 510.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190702592..190706112, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181272022..181276750, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198100586..198104106, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High SULT1A1 expression is associated with high altitude pulmonary edema.
Title: Reverse translating SULT1A1, a potential biomarker in roentgenographically tested rat model of rapid HAPE induction.
SULT1A1 is responsible for bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol.
Title: Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.
Higher SULT1A1 levels were observed in rats as well as in humans exposed to high altitude, when compared to sea-level controls
Title: The proteome of Hypobaric Induced Hypoxic Lung: Insights from Temporal Proteomic Profiling for Biomarker Discovery.
Results suggest that the physiological functions of SULT1A1 in different brain regions can be affected by methamphetamine.
Title: Methamphetamine regulation of sulfotransferase 1A1 and 2A1 expression in rat brain sections.
Data suggest that Sult1a1 and Sult2a1 can be induced in small intestinal mucosa by dietary factors (here, by various levels of caffeine); induction is gender specific and organ specific. Consumption of caffeine may enhance xenobiotic detoxification.
Title: Caffeine induction of sulfotransferases in rat liver and intestine.
mechanistic studies on enzyme activity of purified recombinant Sult1a1 and Sult1a1 in viable liver slices after treatment with the same oxidants [1,1'-azobis(N,N-dimethylformamide); tert-butylhydroperoxide] and the same substrate (7-hydroxycoumarin)
Title: Oxidative modification of rat sulfotransferase 1A1 activity in hepatic tissue slices correlates with effects on the purified enzyme.
Stp1 is important for appropriate regulation of Stk1 function, hemolysin activity, autolysis, and GBS virulence
Title: Serine/threonine phosphatase Stp1 mediates post-transcriptional regulation of hemolysin, autolysis, and virulence of group B Streptococcus.
there is a possible Cys modification mechanism for stress regulation of SULT1A1
Title: Stress regulation of sulfotransferases in male rat liver.

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General gene information

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Markers

BE120712 (e-PCR)
- UniSTS:247426

RH127510 (e-PCR)
- UniSTS:210820

D1Bda35 (e-PCR)
- UniSTS:239782

AI266890 (e-PCR)
- UniSTS:179647

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding	IDA Inferred from Direct Assay more info	PubMed
enables 3'-phosphoadenosine 5'-phosphosulfate binding	ISO Inferred from Sequence Orthology more info
enables aryl sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aryl sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables aryl sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables flavonol 3-sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables steroid sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in 4-nitrophenol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in catecholamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in estrogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ethanol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in flavonoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insecticide	IEP Inferred from Expression Pattern more info	PubMed
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sulfation	ISO Inferred from Sequence Orthology more info
involved_in sulfation	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sulfotransferase 1A1

Names: Aryl sulfotransferase cytosolic, 1A, phenol-preferring, member 3; Phenol sulfotransferase 1a1; aryl sulfotransferase IV; minoxidil sulfotransferase; sulfokinase; sulfotransferase family 1A, phenol-preferring, member 1; sulfotransferase family, cytosolic, 1A, phenol preferring; sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; sulphotransferase family cytosolic 1A phenol-prefering member 1; tyrosine-ester sulfotransferase

NP_114022.1

EC 2.8.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.