Pex2 peroxisomal biogenesis factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pex2provided by RGD
Official Full Name: peroxisomal biogenesis factor 2provided by RGD
Primary source: RGD:61814
See related: EnsemblRapid:ENSRNOG00000008748 AllianceGenome:RGD:61814
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pxmp3
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including fatty acid metabolic process; negative regulation of cell population proliferation; and pexophagy. Predicted to act upstream of or within several processes, including bile acid biosynthetic process; cholesterol homeostasis; and regulation of cholesterol biosynthetic process. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 5B and peroxisome biogenesis disorder 5A. Orthologous to human PEX2 (peroxisomal biogenesis factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 124.2), Muscle (RPKM 95.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (97957479..97973767)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (96050380..96072928)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (98251756..98269185)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AI233233 (e-PCR)
- UniSTS:250136

AI043801 (e-PCR)
- UniSTS:247177

BE111495 (e-PCR)
- UniSTS:245687

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in peroxisome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in pexophagy	IEA Inferred from Electronic Annotation more info
involved_in pexophagy	ISO Inferred from Sequence Orthology more info
involved_in pexophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein destabilization	IEA Inferred from Electronic Annotation more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix, receptor recycling	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome matrix, receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix, receptor recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid starvation	IEA Inferred from Electronic Annotation more info
involved_in response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in very long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cdc73/Paf1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cdc73/Paf1 complex	IEA Inferred from Electronic Annotation more info
part_of Cdc73/Paf1 complex	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peroxisome biogenesis factor 2

Names: PAF-1; peroxin-2; peroxisomal membrane protein 3, 35 kDa; peroxisome assembly factor 1

NP_001375433.1

EC 2.3.2.27

EC 2.3.2.36

NP_001375434.1

EC 2.3.2.27

EC 2.3.2.36

NP_001375435.1

EC 2.3.2.27

EC 2.3.2.36

NP_058930.2

EC 2.3.2.27

EC 2.3.2.36

XP_006232221.1

EC 2.3.2.27

EC 2.3.2.36

XP_008759087.1

EC 2.3.2.27

EC 2.3.2.36

XP_063137709.1

EC 2.3.2.27

EC 2.3.2.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001388504.1 → NP_001375433.1 peroxisome biogenesis factor 2 isoform 1

Status: VALIDATED

Source sequence(s)

FM104606, JAXUCZ010000002

UniProtKB/Swiss-Prot

P24392, Q63733

UniProtKB/TrEMBL

A0A8L2Q557, A6IH90

Conserved Domains (2) summary

cd16526
Location:243 → 284

RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins

pfam04757
Location:27 → 224

Pex2_Pex12; Pex2 / Pex12 amino terminal region
NM_001388505.1 → NP_001375434.1 peroxisome biogenesis factor 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P24392, Q63733

UniProtKB/TrEMBL

A0A8L2Q557, A6IH90

Related

ENSRNOP00000076831.1, ENSRNOT00000095560.2

Conserved Domains (2) summary

cd16526
Location:243 → 284

RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins

pfam04757
Location:27 → 224

Pex2_Pex12; Pex2 / Pex12 amino terminal region
NM_001388506.1 → NP_001375435.1 peroxisome biogenesis factor 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8L2Q557

Conserved Domains (2) summary

cd16526
Location:280 → 321

RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins

pfam04757
Location:64 → 261

Pex2_Pex12; Pex2 / Pex12 amino terminal region
NM_017234.2 → NP_058930.2 peroxisome biogenesis factor 2 isoform 1

Status: VALIDATED

Source sequence(s)

FM078955, FM104606, JAXUCZ010000002

UniProtKB/Swiss-Prot

P24392, Q63733

UniProtKB/TrEMBL

A0A8L2Q557, A6IH90

Related

ENSRNOP00000108095.1, ENSRNOT00000151330.1

Conserved Domains (2) summary

cd16526
Location:243 → 284

RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins

pfam04757
Location:27 → 224

Pex2_Pex12; Pex2 / Pex12 amino terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

97957479..97973767

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232159.4 → XP_006232221.1 peroxisome biogenesis factor 2 isoform X1

UniProtKB/TrEMBL

A0A8L2Q557

Conserved Domains (2) summary

cd16526
Location:280 → 321

RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins

pfam04757
Location:64 → 261

Pex2_Pex12; Pex2 / Pex12 amino terminal region
XM_008760865.4 → XP_008759087.1 peroxisome biogenesis factor 2 isoform X1

UniProtKB/TrEMBL

A0A8L2Q557

Conserved Domains (2) summary

cd16526
Location:280 → 321

RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins

pfam04757
Location:64 → 261

Pex2_Pex12; Pex2 / Pex12 amino terminal region
XM_063281639.1 → XP_063137709.1 peroxisome biogenesis factor 2 isoform X2

UniProtKB/Swiss-Prot

P24392, Q63733

UniProtKB/TrEMBL

A6IH90