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    Dchs1 dachsous cadherin-related 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308912, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dchs1provided by RGD
    Official Full Name
    dachsous cadherin-related 1provided by RGD
    Primary source
    RGD:1309878
    See related
    EnsemblRapid:ENSRNOG00000031643 AllianceGenome:RGD:1309878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pcdh16
    Summary
    Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including heart development; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and hippo signaling. Predicted to act upstream of or within several processes, including condensed mesenchymal cell proliferation; heart development; and post-anal tail morphogenesis. Predicted to be located in apical part of cell. Predicted to be part of catenin complex. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to human DCHS1 (dachsous cadherin-related 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 62.6), Uterus (RPKM 51.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dchs1 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (169516758..169550789, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (160104931..160138958, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (170594981..170629062, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene integrin-linked kinase Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene tripeptidyl peptidase 1 Neighboring gene mitochondrial ribosomal protein L17 Neighboring gene uncharacterized LOC134483767 Neighboring gene GTPase, very large interferon inducible 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development. Cappello S, et al. Nat Genet, 2013 Nov. PMID 24056717
    2. Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex. Ishiuchi T, et al. J Cell Biol, 2009 Jun 15. PMID 19506035, Free PMC Article
    3. Mutations in DCHS1 cause mitral valve prolapse. Durst R, et al. Nature, 2015 Sep 3. PMID 26258302, Free PMC Article
    4. Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Mao Y, et al. Development, 2011 Mar. PMID 21303848, Free PMC Article
    5. Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool. Bagherie-Lachidan M, et al. Development, 2015 Aug 1. PMID 26116661

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration involved in endocardial cushion formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cochlea development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within condensed mesenchymal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within digestive tract development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hippo signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitral valve formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitral valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitral valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nephron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within ossification involved in bone maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pattern specification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pattern specification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-anal tail morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protocadherin-16
    Names
    dachsous 1
    protein dachsous homolog 1
    protocadherin 16 dachsous-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107544.2 → NP_001101014.2  protocadherin-16 precursor

      See identical proteins and their annotated locations for NP_001101014.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      D4ACX8
      UniProtKB/TrEMBL
      A6I7N6
      Related
      ENSRNOP00000040147.4, ENSRNOT00000042865.7
      Conserved Domains (2) summary
      cd11304
      Location:1108 → 1201
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:1356 → 1427
      CA; Cadherin repeats

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      169516758..169550789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229942.4 → XP_006230004.1  protocadherin-16 isoform X1

      See identical proteins and their annotated locations for XP_006230004.1

      UniProtKB/Swiss-Prot
      D4ACX8
      UniProtKB/TrEMBL
      A6I7N6
      Conserved Domains (2) summary
      cd11304
      Location:1108 → 1201
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:1356 → 1427
      CA; Cadherin repeats

    2. XM_039078172.2 → XP_038934100.1  protocadherin-16 isoform X1

      UniProtKB/Swiss-Prot
      D4ACX8
      UniProtKB/TrEMBL
      A6I7N6
      Conserved Domains (2) summary
      cd11304
      Location:1108 → 1201
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:1356 → 1427
      CA; Cadherin repeats
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4ACX8.2 GenPept UniProtKB/Swiss-Prot:D4ACX8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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